ID Q5JRY3_HUMAN Unreviewed; 157 AA. AC Q5JRY3; DT 15-FEB-2005, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 2. DT 02-OCT-2024, entry version 119. DE SubName: Full=Transcription factor 7 like 2 {ECO:0000313|Ensembl:ENSP00000358393.2}; DE Flags: Fragment; GN Name=TCF7L2 {ECO:0000313|Ensembl:ENSP00000358393.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000358393.2, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000358393.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11237011; DOI=10.1038/35057062; RG International Human Genome Sequencing Consortium; RA Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., RA Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., RA Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., RA McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., RA Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., RA Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., RA Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., RA Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., RA Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., RA Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., RA Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., RA Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A., RA Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., RA Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., RA Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., RA Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., RA Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., RA Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., RA Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., RA Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., RA Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., RA Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., RA Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., RA Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., RA Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., RA Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., RA Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., RA Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., RA Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., RA Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., RA Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N., RA Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., RA Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., RA Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., RA Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., RA Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., RA Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., RA Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., RA McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., RA Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., RA Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., RA Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., RA Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., RA Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., RA Shizuya H., Choi S., Chen Y.J.; RT "Initial sequencing and analysis of the human genome."; RL Nature 409:860-921(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000358393.2, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I., RA Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., RA Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., RA Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., RA Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., RA Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., RA Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., RA Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., RA Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., RA Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., RA Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., RA Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., RA Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., RA Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., RA Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., RA Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [3] {ECO:0000313|Ensembl:ENSP00000358393.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496913; DOI=10.1038/nature03001; RG International Human Genome Sequencing Consortium; RT "Finishing the euchromatic sequence of the human genome."; RL Nature 431:931-945(2004). RN [4] {ECO:0000313|Ensembl:ENSP00000358393.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the TCF/LEF family. CC {ECO:0000256|ARBA:ARBA00006569}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL135792; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL158212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL451084; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; Q5JRY3; -. DR SMR; Q5JRY3; -. DR MassIVE; Q5JRY3; -. DR PeptideAtlas; Q5JRY3; -. DR ProteomicsDB; 63121; -. DR Antibodypedia; 31824; 496 antibodies from 34 providers. DR Ensembl; ENST00000369386.5; ENSP00000358393.2; ENSG00000148737.18. DR UCSC; uc057wbh.1; human. DR HGNC; HGNC:11641; TCF7L2. DR VEuPathDB; HostDB:ENSG00000148737; -. DR GeneTree; ENSGT00940000155535; -. DR HOGENOM; CLU_013229_3_1_1; -. DR ChiTaRS; TCF7L2; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000148737; Expressed in lateral nuclear group of thalamus and 198 other cell types or tissues. DR ExpressionAtlas; Q5JRY3; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR CDD; cd21996; HMG-box_TCF7-like; 1. DR Gene3D; 1.10.30.10; High mobility group box domain; 1. DR InterPro; IPR009071; HMG_box_dom. DR InterPro; IPR036910; HMG_box_dom_sf. DR InterPro; IPR024940; TCF/LEF. DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1. DR PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1. DR Pfam; PF00505; HMG_box; 1. DR SMART; SM01366; c-clamp; 1. DR SMART; SM00398; HMG; 1. DR SUPFAM; SSF47095; HMG-box; 1. DR PROSITE; PS50118; HMG_BOX_2; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5JRY3, KW ECO:0007829|ProteomicsDB:Q5JRY3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}. FT DOMAIN 30..98 FT /note="HMG box" FT /evidence="ECO:0000259|PROSITE:PS50118" FT DNA_BIND 30..98 FT /note="HMG box" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 97..124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 13..31 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000358393.2" SQ SEQUENCE 157 AA; 18297 MW; CB00A6CED4938D18 CRC64; QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETND LSAPKKCRAR FGLDQQNNWC GPCRCKYSKE VSGTVRA //