ID Q5JRY3_HUMAN Unreviewed; 157 AA. AC Q5JRY3; DT 15-FEB-2005, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 2. DT 10-FEB-2021, entry version 101. DE SubName: Full=Transcription factor 7-like 2 {ECO:0000313|Ensembl:ENSP00000358393}; DE Flags: Fragment; GN Name=TCF7L2 {ECO:0000313|Ensembl:ENSP00000358393}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000358393, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000358393, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000358393} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the TCF/LEF family. CC {ECO:0000256|ARBA:ARBA00006569}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL135792; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL158212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL451084; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; Q5JRY3; -. DR PRIDE; Q5JRY3; -. DR ProteomicsDB; 63121; -. DR Antibodypedia; 31824; 457 antibodies. DR Ensembl; ENST00000369386; ENSP00000358393; ENSG00000148737. DR UCSC; uc057wbh.1; human. DR HGNC; HGNC:11641; TCF7L2. DR OpenTargets; ENSG00000148737; -. DR VEuPathDB; HostDB:ENSG00000148737.15; -. DR GeneTree; ENSGT00940000155535; -. DR HOGENOM; CLU_013229_3_1_1; -. DR ChiTaRS; TCF7L2; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000148737; Expressed in lateral nuclear group of thalamus and 241 other tissues. DR ExpressionAtlas; Q5JRY3; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.10.30.10; -; 1. DR InterPro; IPR009071; HMG_box_dom. DR InterPro; IPR036910; HMG_box_dom_sf. DR InterPro; IPR024940; TCF/LEF. DR PANTHER; PTHR10373; PTHR10373; 1. DR Pfam; PF00505; HMG_box; 1. DR SMART; SM00398; HMG; 1. DR SUPFAM; SSF47095; SSF47095; 1. DR PROSITE; PS50118; HMG_BOX_2; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267}; KW Proteomics identification {ECO:0000213|EPD:Q5JRY3, KW ECO:0000213|MaxQB:Q5JRY3, ECO:0000213|PeptideAtlas:Q5JRY3, KW ECO:0000213|ProteomicsDB:Q5JRY3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}. FT DOMAIN 30..98 FT /note="HMG box" FT /evidence="ECO:0000259|PROSITE:PS50118" FT DNA_BIND 30..98 FT /note="HMG box" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 97..124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 13..31 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000358393" SQ SEQUENCE 157 AA; 18297 MW; CB00A6CED4938D18 CRC64; QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETND LSAPKKCRAR FGLDQQNNWC GPCRCKYSKE VSGTVRA //