ID PURO_PYRKO Reviewed; 198 AA. AC Q5JD29; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 15-DEC-2009, entry version 28. DE RecName: Full=IMP cyclohydrolase; DE EC=3.5.4.10; DE AltName: Full=Inosinicase; DE AltName: Full=IMP synthetase; GN Name=purO; OrderedLocusNames=TK0430; OS Pyrococcus kodakaraensis (Thermococcus kodakaraensis). OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Thermococcus. OX NCBI_TaxID=311400; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KOD1; RX PubMed=15710748; DOI=10.1101/gr.3003105; RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.; RT "Complete genome sequence of the hyperthermophilic archaeon RT Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus RT genomes."; RL Genome Res. 15:352-363(2005). CC -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4- CC carboxamide ribonucleotide to IMP (By similarity). CC -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D- CC ribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; CC IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- CC carboxamide: step 1/1. CC -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP006878; BAD84619.1; -; Genomic_DNA. DR RefSeq; YP_182843.1; -. DR HSSP; O27099; 1KUU. DR STRING; Q5JD29; -. DR GeneID; 3235123; -. DR GenomeReviews; AP006878_GR; TK0430. DR KEGG; tko:TK0430; -. DR NMPDR; fig|69014.3.peg.315; -. DR HOGENOM; HBG539724; -. DR OMA; TNGSHTD; -. DR BioCyc; TKOD69014:TK0430-MON; -. DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:HAMAP. DR GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro. DR HAMAP; MF_00705; -; 1. DR InterPro; IPR010191; IMP_cyclohydrolase. DR InterPro; IPR020600; IMP_cyclohydrolase-like. DR Gene3D; G3DSA:3.60.20.20; PurO_cyclohydro; 1. DR Pfam; PF07826; IMP_cyclohyd; 1. DR PIRSF; PIRSF004866; IMP_cclhdr_arch; 1. PE 3: Inferred from homology; KW Complete proteome; Hydrolase; Purine biosynthesis. FT CHAIN 1 198 IMP cyclohydrolase. FT /FTId=PRO_0000349170. SQ SEQUENCE 198 AA; 22625 MW; BC2E7E7E0D8FAE6F CRC64; MRYVGRTLGI GLNNGKPFAF YLLCSRSFPN RRAVVKGNGV YILNQTETEN PYVSYPVVRL MEDYAVVTNG LHTDFIAQAL EWERPRKALV HVLDALDYER DDYSTPRIAG IIQHGGRRGW LGFVGRDMLW MRELELEEGK AFLTATYNME GFESIELAFS TPEELAEKVM ELPFEHKVLA IGIVENEKGW ELSFTPSL //