ID DB121_HUMAN Reviewed; 76 AA. AC Q5J5C9; A1L4N1; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 20-JUN-2018, entry version 93. DE RecName: Full=Beta-defensin 121; DE AltName: Full=Beta-defensin 21; DE Short=DEFB-21; DE AltName: Full=Defensin, beta 121; DE Flags: Precursor; GN Name=DEFB121; Synonyms=DEFB21; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Testis; RX PubMed=15772680; DOI=10.1038/sj.gene.6364184; RA Radhakrishnan Y., Hamil K.G., Yenugu S., Young S.L., French F.S., RA Hall S.H.; RT "Identification, characterization, and evolution of a primate beta- RT defensin gene cluster."; RL Genes Immun. 6:203-210(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}. CC -!- INTERACTION: CC Q8N205:SYNE4; NbExp=3; IntAct=EBI-10244198, EBI-7131783; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Abundant expression in the male reproductive CC tract only. {ECO:0000269|PubMed:15772680}. CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY501000; AAS87294.1; -; mRNA. DR EMBL; AL121751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC130607; AAI30608.1; -; mRNA. DR EMBL; BC130609; AAI30610.1; -; mRNA. DR CCDS; CCDS33456.1; -. DR RefSeq; NP_001011878.1; NM_001011878.2. DR UniGene; Hs.272294; -. DR ProteinModelPortal; Q5J5C9; -. DR SMR; Q5J5C9; -. DR BioGrid; 128847; 11. DR IntAct; Q5J5C9; 2. DR STRING; 9606.ENSP00000417128; -. DR iPTMnet; Q5J5C9; -. DR PhosphoSitePlus; Q5J5C9; -. DR BioMuta; DEFB121; -. DR DMDM; 61212937; -. DR PaxDb; Q5J5C9; -. DR PeptideAtlas; Q5J5C9; -. DR PRIDE; Q5J5C9; -. DR ProteomicsDB; 62979; -. DR DNASU; 245934; -. DR Ensembl; ENST00000376314; ENSP00000417128; ENSG00000204548. DR GeneID; 245934; -. DR KEGG; hsa:245934; -. DR UCSC; uc002wvv.3; human. DR CTD; 245934; -. DR EuPathDB; HostDB:ENSG00000204548.3; -. DR GeneCards; DEFB121; -. DR HGNC; HGNC:18101; DEFB121. DR MIM; 616075; gene. DR neXtProt; NX_Q5J5C9; -. DR OpenTargets; ENSG00000204548; -. DR PharmGKB; PA38497; -. DR eggNOG; ENOG410JKRC; Eukaryota. DR eggNOG; ENOG41113KI; LUCA. DR GeneTree; ENSGT00730000111628; -. DR HOGENOM; HOG000246960; -. DR HOVERGEN; HBG097015; -. DR InParanoid; Q5J5C9; -. DR OMA; EVFHILC; -. DR OrthoDB; EOG091G18PL; -. DR PhylomeDB; Q5J5C9; -. DR Reactome; R-HSA-1461957; Beta defensins. DR Reactome; R-HSA-1461973; Defensins. DR GenomeRNAi; 245934; -. DR PRO; PR:Q5J5C9; -. DR Proteomes; UP000005640; Chromosome 20. DR Bgee; ENSG00000204548; -. DR CleanEx; HS_DEFB121; -. DR Genevisible; Q5J5C9; HS. DR GO; GO:0009986; C:cell surface; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR InterPro; IPR025933; Beta_defensin. DR PANTHER; PTHR15001; PTHR15001; 1. DR Pfam; PF13841; Defensin_beta_2; 1. DR ProDom; PD866254; PD866254; 1. PE 1: Evidence at protein level; KW Antibiotic; Antimicrobial; Complete proteome; Defensin; KW Disulfide bond; Reference proteome; Secreted; Signal. FT SIGNAL 1 15 {ECO:0000255}. FT CHAIN 16 76 Beta-defensin 121. FT /FTId=PRO_0000006991. FT DISULFID 23 50 {ECO:0000250}. FT DISULFID 30 44 {ECO:0000250}. FT DISULFID 34 51 {ECO:0000250}. SQ SEQUENCE 76 AA; 8456 MW; 1B80ECF2491B2E18 CRC64; MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC CVDPKYVPVK PKLTDTNTSL ESTSAV //