ID DB121_HUMAN Reviewed; 76 AA. AC Q5J5C9; A1L4N1; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 16-OCT-2013, entry version 66. DE RecName: Full=Beta-defensin 121; DE AltName: Full=Beta-defensin 21; DE Short=DEFB-21; DE AltName: Full=Defensin, beta 121; DE Flags: Precursor; GN Name=DEFB121; Synonyms=DEFB21; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Epididymis; RA Yashwanth R., Hamil K.G., Yenugu S., French F.S., Hall S.H.; RT "Differential expression of a primate beta defensin gene cluster RT specific to male reproductive tract."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Has antibacterial activity (Potential). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- SIMILARITY: Belongs to the beta-defensin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY501000; AAS87294.1; -; mRNA. DR EMBL; AL121751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC130607; AAI30608.1; -; mRNA. DR EMBL; BC130609; AAI30610.1; -; mRNA. DR IPI; IPI00553027; -. DR RefSeq; NP_001011878.1; NM_001011878.2. DR UniGene; Hs.272294; -. DR ProteinModelPortal; Q5J5C9; -. DR STRING; 9606.ENSP00000417128; -. DR DMDM; 61212937; -. DR PaxDb; Q5J5C9; -. DR PRIDE; Q5J5C9; -. DR DNASU; 245934; -. DR Ensembl; ENST00000376314; ENSP00000417128; ENSG00000204548. DR GeneID; 245934; -. DR KEGG; hsa:245934; -. DR UCSC; uc002wvv.2; human. DR CTD; 245934; -. DR GeneCards; GC20M029992; -. DR HGNC; HGNC:18101; DEFB121. DR HPA; HPA045290; -. DR neXtProt; NX_Q5J5C9; -. DR PharmGKB; PA38497; -. DR eggNOG; NOG112903; -. DR HOGENOM; HOG000246960; -. DR HOVERGEN; HBG097015; -. DR InParanoid; Q5J5C9; -. DR OMA; EVFHILC; -. DR OrthoDB; EOG41RPWP; -. DR Reactome; REACT_6900; Immune System. DR NextBio; 91801; -. DR PRO; PR:Q5J5C9; -. DR Bgee; Q5J5C9; -. DR CleanEx; HS_DEFB121; -. DR Genevestigator; Q5J5C9; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR InterPro; IPR025933; Beta_defensin. DR Pfam; PF13841; Defensin_beta_2; 1. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Complete proteome; Defensin; KW Disulfide bond; Reference proteome; Secreted; Signal. FT SIGNAL 1 15 Potential. FT CHAIN 16 76 Beta-defensin 121. FT /FTId=PRO_0000006991. FT DISULFID 23 50 By similarity. FT DISULFID 30 44 By similarity. FT DISULFID 34 51 By similarity. SQ SEQUENCE 76 AA; 8456 MW; 1B80ECF2491B2E18 CRC64; MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC CVDPKYVPVK PKLTDTNTSL ESTSAV //