ID DB121_HUMAN STANDARD; PRT; 76 AA. AC Q5J5C9; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 18-APR-2006, entry version 14. DE Beta-defensin 121 precursor (Defensin, beta 121) (Beta-defensin 21) DE (DEFB-21). GN Name=DEFB121; Synonyms=DEFB21; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Epididymis; RA Yashwanth R., Hamil K.G., Yenugu S., French F.S., Hall S.H.; RT "Differential expression of a primate beta defensin gene cluster RT specific to male reproductive tract."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Has antibacterial activity (Potential). CC -!- SUBCELLULAR LOCATION: Secreted protein (Potential). CC -!- SIMILARITY: Belongs to the beta-defensin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY501000; AAS87294.1; -; mRNA. DR UniGene; Hs.272294; -. DR HGNC; HGNC:18101; DEFB121. DR GO; GO:0005576; C:extracellular region; ISS. DR GO; GO:0006965; P:anti-Gram-positive bacterial polypeptide in...; ISS. KW Antibiotic; Antimicrobial; Defensin; Signal. FT SIGNAL 1 15 Potential. FT CHAIN 16 76 Beta-defensin 121. FT /FTId=PRO_0000006991. FT DISULFID 23 50 By similarity. FT DISULFID 30 44 By similarity. FT DISULFID 34 51 By similarity. SQ SEQUENCE 76 AA; 8456 MW; 1B80ECF2491B2E18 CRC64; MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC CVDPKYVPVK PKLTDTNTSL ESTSAV //