ID Q5IJJ0_9NEOP PRELIMINARY; PRT; 269 AA. AC Q5IJJ0; DT 15-FEB-2005, integrated into UniProtKB/TrEMBL. DT 15-FEB-2005, sequence version 1. DT 21-FEB-2006, entry version 8. DE Cytochrome oxidase subunit I (Fragment). GN Name=COI; OS Ithomia iphianassa panamensis. OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; OC Papilionoidea; Nymphalidae; Danainae; Ithomiini; Ithomiina; Ithomia. OX NCBI_TaxID=306001; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=15683934; DOI=10.1016/j.ympev.2004.10.021; RA Mallarino R., Bermingham E., Willmott K.R., Whinnett A., Jiggins C.D.; RT "Molecular systematics of the butterfly genus Ithomia (Lepidoptera: RT Ithomiinae): a composite phylogenetic hypothesis based on seven RT genes."; RL Mol. Phylogenet. Evol. 34:625-644(2005). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) = 4 ferricytochrome CC c + 2 H(2)O. CC -!- PATHWAY: Respiratory chain; terminal step. CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane; CC multi-pass membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY713064; AAW56264.1; -; Genomic_DNA. DR EMBL; AY713065; AAW56266.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005746; C:mitochondrial electron transport chain; IEA. DR GO; GO:0005739; C:mitochondrion; IEA. DR GO; GO:0019866; C:organelle inner membrane; IEA. DR GO; GO:0005507; F:copper ion binding; IEA. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0006118; P:electron transport; IEA. DR InterPro; IPR000883; COX1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR PROSITE; PS50855; COX1; 1. KW Copper; Electron transport; Heme; Inner membrane; Membrane; KW Mitochondrion; Oxidoreductase; Respiratory chain; Transmembrane; KW Transport. FT NON_TER 1 1 SQ SEQUENCE 269 AA; 30366 MW; 7079902F78F8BB63 CRC64; LILPGFGMIS HIISQESGKK ETFGSLGMIY AMMAIGLLGF IVWAHHMFTV GMDIDTRAYF TSATMIIAVP TGIKIFSWLA TLHGTQINYS PSILWSLGFV FLFTVGGLTG VILANSSIDI TLHDTYYVVA HFHYVLSMGA VFAILGGFIH WYPLFTGLIM NPYLLKIQFF TMFLGVNITF FPQHFLGLAG MPRRYSDYPD SFMSWNIISS LGSYISLLSM MMIIIIIWES MINQRIILFS LNMPSSIEWY QNLPPAEHSY NELPILSNF //