ID IKBN1_MDBVW Reviewed; 139 AA. AC Q5I129; DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 22-FEB-2023, entry version 60. DE RecName: Full=I-Kappa-B like protein N1; GN Name=N2; OS Microplitis demolitor bracovirus (isolate Webb) (MdBV). OC Viruses; Polydnaviriformidae; Bracoviriform. OX NCBI_TaxID=654919; OH NCBI_TaxID=69319; Microplitis demolitor. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=16380146; DOI=10.1016/j.virol.2005.11.010; RA Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E., RA Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S., RA Thoetkiattikul H., Turnbull M.W., Witherell R.A.; RT "Polydnavirus genomes reflect their dual roles as mutualists and RT pathogens."; RL Virology 347:160-174(2006). CC -!- FUNCTION: Suppresses the host immune response through NF-kappa-B CC inactivation. Possesses ankyrin repeat domain required for NF-kappa-B CC binding but lack the regulatory regions required for dissociation from CC NF-kappa-B and degradation. Therefore, prevents host NF-kappa-B release CC and subsequent activation (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the polydnaviridae I-Kappa-B-like protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY875689; AAW51804.1; -; Genomic_DNA. DR RefSeq; YP_239399.1; NC_007039.1. DR SMR; Q5I129; -. DR GeneID; 5075835; -. DR KEGG; vg:5075835; -. DR Proteomes; UP000008168; Genome. DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1. DR PANTHER; PTHR46680:SF1; NF-KAPPA-B INHIBITOR ALPHA; 1. DR Pfam; PF12796; Ank_2; 1. DR SMART; SM00248; ANK; 3. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR PROSITE; PS50297; ANK_REP_REGION; 1. PE 3: Inferred from homology; KW ANK repeat; Host-virus interaction; Inhibition of host NF-kappa-B by virus; KW Reference proteome; Repeat. FT CHAIN 1..139 FT /note="I-Kappa-B like protein N1" FT /id="PRO_0000405368" FT REPEAT 16..48 FT /note="ANK 1" FT REPEAT 54..87 FT /note="ANK 2" FT REPEAT 92..122 FT /note="ANK 3" SQ SEQUENCE 139 AA; 15850 MW; 466871AD75BF0C45 CRC64; MEFSVRTIIN NKVYINGENL LHAMCRHGNS LALSIIAQSI NKNYQYLLNE YNREGRKCIH IAAVMHKGQV ATELIIILLN FGADVNGRVL CTGDTVLHIA VYLKDYYLAE WLCRRSGINI NARNICRTHT ISNSTEEKR //