ID IKBN1_MDBVW Reviewed; 139 AA. AC Q5I129; DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 07-JAN-2015, entry version 44. DE RecName: Full=I-Kappa-B like protein N1; GN Name=N2; OS Microplitis demolitor bracovirus (isolate Webb) (MdBV). OC Viruses; dsDNA viruses, no RNA stage; Polydnaviridae; Bracovirus. OX NCBI_TaxID=654919; OH NCBI_TaxID=69319; Microplitis demolitor. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=16380146; DOI=10.1016/j.virol.2005.11.010; RA Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., RA Barney W.E., Kadash K., Kroemer J.A., Lindstrom K.G., RA Rattanadechakul W., Shelby K.S., Thoetkiattikul H., Turnbull M.W., RA Witherell R.A.; RT "Polydnavirus genomes reflect their dual roles as mutualists and RT pathogens."; RL Virology 347:160-174(2006). CC -!- FUNCTION: Suppresses the host immune response through NF-kappa-B CC inactivation. Possesses ankyrin repeat domain required for NF- CC kappa-B binding but lack the regulatory regions required for CC dissociation from NF-kappa-B and degradation. Therefore, prevents CC host NF-kappa-B release and subsequent activation (By similarity). CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the polydnaviridae I-Kappa-B-like protein CC family. {ECO:0000305}. CC -!- SIMILARITY: Contains 3 ANK repeats. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY875689; AAW51804.1; -; Genomic_DNA. DR RefSeq; YP_239399.1; NC_007039.1. DR ProteinModelPortal; Q5I129; -. DR GeneID; 5075835; -. DR Proteomes; UP000008168; Genome. DR GO; GO:0039644; P:suppression by virus of host NF-kappaB transcription factor activity; IEA:UniProtKB-KW. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR Pfam; PF12796; Ank_2; 1. DR SMART; SM00248; ANK; 3. DR SUPFAM; SSF48403; SSF48403; 1. DR PROSITE; PS50297; ANK_REP_REGION; 1. PE 3: Inferred from homology; KW ANK repeat; Complete proteome; Host-virus interaction; KW Inhibition of host NF-kappa-B by virus; Reference proteome; Repeat. FT CHAIN 1 139 I-Kappa-B like protein N1. FT /FTId=PRO_0000405368. FT REPEAT 16 48 ANK 1. FT REPEAT 54 87 ANK 2. FT REPEAT 92 122 ANK 3. SQ SEQUENCE 139 AA; 15850 MW; 466871AD75BF0C45 CRC64; MEFSVRTIIN NKVYINGENL LHAMCRHGNS LALSIIAQSI NKNYQYLLNE YNREGRKCIH IAAVMHKGQV ATELIIILLN FGADVNGRVL CTGDTVLHIA VYLKDYYLAE WLCRRSGINI NARNICRTHT ISNSTEEKR //