ID Q5GDB7_CVHSA Unreviewed; 1255 AA. AC Q5GDB7; DT 01-MAR-2005, integrated into UniProtKB/TrEMBL. DT 01-MAR-2005, sequence version 1. DT 05-JUN-2019, entry version 33. DE SubName: Full=Spike glycoprotein {ECO:0000313|EMBL:AAV49719.1}; OS SARS coronavirus PC4-115. OC Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; OC Orthocoronavirinae; Betacoronavirus; Sarbecovirus. OX NCBI_TaxID=296837 {ECO:0000313|EMBL:AAV49719.1}; RN [1] {ECO:0000313|EMBL:AAV49719.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15695582; DOI=10.1073/pnas.0409608102; RA Song H.D., Tu C.C., Zhang G.W., Wang S.Y., Zheng K., Lei L.C., RA Chen Q.X., Gao Y.W., Zhou H.Q., Xiang H., Zheng H.J., Chern S.W., RA Cheng F., Pan C.M., Xuan H., Chen S.J., Luo H.M., Zhou D.H., Liu Y.F., RA He J.F., Qin P.Z., Li L.H., Ren Y.Q., Liang W.J., Yu Y.D., RA Anderson L., Wang M., Xu R.H., Wu X.W., Zheng H.Y., Chen J.D., RA Liang G., Gao Y., Liao M., Fang L., Jiang L.Y., Li H., Chen F., Di B., RA He L.J., Lin J.Y., Tong S., Kong X., Du L., Hao P., Tang H., RA Bernini A., Yu X.J., Spiga O., Guo Z.M., Pan H.Y., He W.Z., RA Manuguerra J.C., Fontanet A., Danchin A., Niccolai N., Li Y.X., RA Wu C.I., Zhao G.P.; RT "Cross-host evolution of severe acute respiratory syndrome coronavirus RT in palm civet and human."; RL Proc. Natl. Acad. Sci. U.S.A. 102:2430-2435(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY627044; AAV49719.1; -; Genomic_RNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0061025; P:membrane fusion; IEA:InterPro. DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:InterPro. DR Gene3D; 1.20.5.790; -; 1. DR InterPro; IPR002552; Corona_S2. DR InterPro; IPR027400; S_HR2. DR InterPro; IPR032500; Spike_N. DR InterPro; IPR018548; Spike_rcpt-bd. DR InterPro; IPR036326; Spike_rcpt-bd_sf. DR Pfam; PF01601; Corona_S2; 1. DR Pfam; PF16451; Spike_NTD; 1. DR Pfam; PF09408; Spike_rec_bind; 1. DR SUPFAM; SSF143587; SSF143587; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1196 1218 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 100 280 Spike_NTD. {ECO:0000259|Pfam:PF16451}. FT DOMAIN 317 568 Spike_rec_bind. {ECO:0000259|Pfam: FT PF09408}. FT DOMAIN 658 1252 Corona_S2. {ECO:0000259|Pfam:PF01601}. FT COILED 1158 1185 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1255 AA; 139173 MW; 696C5EA96FB5426F CRC64; MFIFLLFLTL TSGSDLDRCT TFDDVQAPNY TQHTSSMRGV YYPDEIFRSD TLYLTQDLFL PFYSNVTGFH TINHTFDNPV IPFKDGIYFA ATEKSNVVRG WVFGSTMNNK SQSVIIINNS TNVVIRACNF ELCDNPFFVV SKPMGTRTHT MIFDNAFNCT FEYISDAFSL DVSEKSGNFK HLREFVFKNK DGFLYVYKGY QPIDVVRDLP SGFNTLKPIF KLPLGINITN FRAILTAFSP AQDTWGTSAA AYFVGYLKPT TFMLKYDENG TITDAVDCSQ NPLAELKCSV KSFEIDKGIY QTSNFRVVPS GDVVRFPNIT NLCPFGEVFN ATKFPSVYAW ERKRISNCVA DYSVLYNSTS FSTFKCYGVS ATKLNDLCFS NVYADSFVVK GDDVRQIAPG QTGVIADYNY KLPDDFMGCV LAWNTRNIDA TSTGNYNYKY RYLRHGKLRP FERDISNVPF SPDGKPCTPP APNCYWPLNG YGFYTTSGIG YQPYRVVVLS FELLNAPATV CGPKLSTDLI KNQCVNFNFN GLTGTGVLTP SSKRFQPFQQ FGRDVSDFTD SVRDPKTSEI LDISPCSFGG VSVITPGTNA SSEVAVLYQD VNCTDVSTLI HAEQLTPAWR IYSTGNNVFQ TQAGCLIGAE HVDTSYECDI PIGAGICASY HTVSSLRSTS QKSIVAYTMS LGADSSIAYS NNTIAIPTNF SISITTEVMP VSMAKTSVDC NMYICGDSTE CANLLLQYGS FCRQLNRALS GIAAEQDRNT REVFVQVKQM YKTPTLKDFG GFNFSQILPD PLKPTKRSFI EDLLFNKVTL ADAGFMKQYG ECLGDINARD LICAQKFNGL TVLPPLLTDD MIAAYTAALV SGTATAGWTF GAGAALQIPF AMQMAYRFNG IGVTQNVLYE NQKQIANQFN KAISQIQESL TTTSTALGKL QDVVNQNAQA LNTLVKQLSS NFGAISSVLN DILSRLDKVE AEVQIDRLIT GRLQSLQTYV TQQLIRAAEI RASANLAATK MSECVLGQSK RVDFCGKGYH LMSFPQAAPH GVVFLHVTYV PSQERNFTTA PAICHEGKAY FPREGVFVFN GTSWFITQRN FFSPQIITTD NTFVSGNCDV VIGIINNTVY DPLQPELDSF KEELDKYFKN HTSPDVDLGD ISGINASVVN IQEEIDRLNE VAKNLNESLI DLQELGKYEQ YIKWPWYVWL GFIAGLIAIV MVTILLCCMT SCCSCLKGAC SCGSCCKFDE DDSEPVLKGV KLHYT //