ID DNAA_ALIF1 Reviewed; 469 AA. AC Q5E8Z2; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2005, sequence version 1. DT 03-AUG-2022, entry version 95. DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377}; GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=VF_0009; OS Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri). OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; OC Aliivibrio. OX NCBI_TaxID=312309; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700601 / ES114; RX PubMed=15703294; DOI=10.1073/pnas.0409900102; RA Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., RA Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., RA Stevens A., Visick K., Whistler C., Greenberg E.P.; RT "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with RT pathogenic congeners."; RL Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005). CC -!- FUNCTION: Plays an important role in the initiation and regulation of CC chromosomal replication. Binds to the origin of replication; it binds CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. CC {ECO:0000255|HAMAP-Rule:MF_00377}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}. CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP- CC Rule:MF_00377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000020; AAW84504.1; -; Genomic_DNA. DR RefSeq; WP_005416782.1; NC_006840.2. DR RefSeq; YP_203392.1; NC_006840.2. DR AlphaFoldDB; Q5E8Z2; -. DR SMR; Q5E8Z2; -. DR STRING; 312309.VF_0009; -. DR EnsemblBacteria; AAW84504; AAW84504; VF_0009. DR GeneID; 64241602; -. DR KEGG; vfi:VF_0009; -. DR PATRIC; fig|312309.11.peg.10; -. DR eggNOG; COG0593; Bacteria. DR HOGENOM; CLU_026910_0_1_6; -. DR OMA; REFNPLF; -. DR OrthoDB; 219876at2; -. DR Proteomes; UP000000537; Chromosome I. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule. DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule. DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule. DR CDD; cd06571; Bac_DnaA_C; 1. DR Gene3D; 1.10.1750.10; -; 1. DR Gene3D; 3.30.300.180; -; 1. DR Gene3D; 3.40.50.300; -; 1. DR HAMAP; MF_00377; DnaA_bact; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001957; Chromosome_initiator_DnaA. DR InterPro; IPR020591; Chromosome_initiator_DnaA-like. DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS. DR InterPro; IPR013317; DnaA. DR InterPro; IPR013159; DnaA_C. DR InterPro; IPR024633; DnaA_N_dom. DR InterPro; IPR038454; DnaA_N_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR010921; Trp_repressor/repl_initiator. DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1. DR Pfam; PF00308; Bac_DnaA; 1. DR Pfam; PF08299; Bac_DnaA_C; 1. DR Pfam; PF11638; DnaA_N; 1. DR PRINTS; PR00051; DNAA. DR SMART; SM00382; AAA; 1. DR SMART; SM00760; Bac_DnaA_C; 1. DR SUPFAM; SSF48295; SSF48295; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR00362; DnaA; 1. DR PROSITE; PS01008; DNAA; 1. PE 3: Inferred from homology; KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding; KW Reference proteome. FT CHAIN 1..469 FT /note="Chromosomal replication initiator protein DnaA" FT /id="PRO_0000114296" FT BINDING 174..181 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377" SQ SEQUENCE 469 AA; 52803 MW; C838973210CC6B8D CRC64; MSSSLWLQCL QRLQEELPSA EFSMWVRPLQ AELNDNTLTL FAPNRFVLDW VRDKYLNSIN SLLNEFCGND IPTLRFEVGS KPVSAPAVPK QTAADVAAAT SAPAQLQARQ SVHKPWESEG AGPVAADLNH RSNVNPKHKF TNFVEGKSNQ LGLAAARQVS DNPGTAYNPL FLYGGTGLGK THLLHAVGNA IVDSKPDARV VYMHSERFVQ DMVKALQNNA IEEFKRYYRS VDALLIDDIQ FFANKERSQE EFFHTFNALL EGNQQIILTS DRYPKEINGV EDRLKSRFGW GLTVAIEPPE LETRVAILMK KAEDHQIHLA DEVAFFIAKR LRSNVRELEG ALNRVIANAN FTGRAITIDF VREALRDLLA LQEKLVTIDN IQKTVAEYYK IKMADLLSKR RSRSVARPRQ LAMALSKELT NHSLPEIGDA FGGRDHTTVL HACRKIAQLR EESHDIKEDY SNLIRTLSS //