ID Q5C141_SCHJA Unreviewed; 262 AA. AC Q5C141; DT 12-APR-2005, integrated into UniProtKB/TrEMBL. DT 12-APR-2005, sequence version 1. DT 14-DEC-2022, entry version 77. DE SubName: Full=Cathepsin D (Lysosomal aspartyl protease) {ECO:0000313|EMBL:CAX72341.1}; DE EC=3.4.23.5 {ECO:0000313|EMBL:CAX72341.1}; GN Name=ctsd {ECO:0000313|EMBL:CAX72341.1}; OS Schistosoma japonicum (Blood fluke). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma. OX NCBI_TaxID=6182 {ECO:0000313|EMBL:AAX26634.1}; RN [1] {ECO:0000313|EMBL:AAX26634.1} RP NUCLEOTIDE SEQUENCE. RA Han Z.; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAX26634.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16617374; DOI=10.1371/journal.ppat.0020029; RA Liu F., Lu J., Hu W., Wang S.Y., Cui S.J., Chi M., Yan Q., Wang X.R., RA Song H.D., Xu X.N., Wang J.J., Zhang X.L., Zhang X., Wang Z.Q., Xue C.L., RA Brindley P.J., McManus D.P., Yang P.Y., Feng Z., Chen Z., Han Z.G.; RT "New perspectives on host-parasite interplay by comparative transcriptomic RT and proteomic analyses of Schistosoma japonicum."; RL PLoS Pathog. 2:268-281(2006). RN [3] {ECO:0000313|EMBL:CAX72341.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Anhui {ECO:0000313|EMBL:CAX72341.1}; RX DOI=10.1038/nature08140; RA Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P., RA Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.; RT "The Schistosoma japonicum genome reveals features of host-parasite RT interplay."; RL Nature 460:345-351(2009). RN [4] {ECO:0000313|EMBL:CAX72341.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Anhui {ECO:0000313|EMBL:CAX72341.1}; RA Gang L.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the peptidase A1 family. CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY810745; AAX26634.1; -; mRNA. DR EMBL; FN316610; CAX72341.1; -; mRNA. DR AlphaFoldDB; Q5C141; -. DR MEROPS; A01.009; -. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR Gene3D; 2.40.70.10; -; 2. DR InterPro; IPR001461; Aspartic_peptidase_A1. DR InterPro; IPR001969; Aspartic_peptidase_AS. DR InterPro; IPR033121; PEPTIDASE_A1. DR InterPro; IPR021109; Peptidase_aspartic_dom_sf. DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1. DR Pfam; PF00026; Asp; 1. DR PRINTS; PR00792; PEPSIN. DR SUPFAM; SSF50630; Acid proteases; 1. DR PROSITE; PS00141; ASP_PROTEASE; 1. DR PROSITE; PS51767; PEPTIDASE_A1; 1. PE 2: Evidence at transcript level; KW Aspartyl protease {ECO:0000256|RuleBase:RU000454}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2}; KW Hydrolase {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:CAX72341.1}; KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:CAX72341.1}. FT DOMAIN 1..213 FT /note="Peptidase A1" FT /evidence="ECO:0000259|PROSITE:PS51767" FT DISULFID 94..98 FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2" FT DISULFID 137..174 FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2" SQ SEQUENCE 262 AA; 28687 MW; B83065B5693118A1 CRC64; MAKFDGILGM AYPSLAVGGV TPVFVNMIKQ GVVDSPVFSF YLSRNITNVL GGELMIGGID DKYYTGEINY VNLTEKSYWL FKMDNLTISD LSICTDGCQA IADTGTSMIA GPTDEVKQIN QKLGATHLPG GIYTVSCDVI NNLPSIDFVI NGKHMTLEPT DYIMKVSKLG SEICLTGFIG MDLPRKKLWI LGDVFIGKFY TIFDMGKNRV GFAKAVKPDS SYHHTKVYSP MLRLFPAQSI PKVAPKSPNG VFAFSKLLHD AN //