ID   Q5C141_SCHJA            Unreviewed;       262 AA.
AC   Q5C141;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   13-APR-2016, entry version 54.
DE   SubName: Full=Cathepsin D (Lysosomal aspartyl protease) {ECO:0000313|EMBL:CAX72341.1};
DE            EC=3.4.23.5 {ECO:0000313|EMBL:CAX72341.1};
GN   Name=ctsd {ECO:0000313|EMBL:CAX72341.1};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182 {ECO:0000313|EMBL:AAX26634.1};
RN   [1] {ECO:0000313|EMBL:AAX26634.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Han Z.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAX26634.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16617374; DOI=10.1371/journal.ppat.0020029;
RA   Liu F., Lu J., Hu W., Wang S.Y., Cui S.J., Chi M., Yan Q., Wang X.R.,
RA   Song H.D., Xu X.N., Wang J.J., Zhang X.L., Zhang X., Wang Z.Q.,
RA   Xue C.L., Brindley P.J., McManus D.P., Yang P.Y., Feng Z., Chen Z.,
RA   Han Z.G.;
RT   "New perspectives on host-parasite interplay by comparative
RT   transcriptomic and proteomic analyses of Schistosoma japonicum.";
RL   PLoS Pathog. 2:268-281(2006).
RN   [3] {ECO:0000313|EMBL:CAX72341.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX72341.1};
RX   DOI=10.1038/nature08140;
RA   Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J.,
RA   McManus D.P., Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G.,
RA   Chen Z.;
RT   "The Schistosoma japonicum genome reveals features of host-parasite
RT   interplay.";
RL   Nature 460:345-351(2009).
RN   [4] {ECO:0000313|EMBL:CAX72341.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX72341.1};
RA   Gang L.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|RuleBase:RU000454}.
CC   -!- SIMILARITY: Contains peptidase A1 domain.
CC       {ECO:0000256|SAAS:SAAS00530880}.
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DR   EMBL; AY810745; AAX26634.1; -; mRNA.
DR   EMBL; FN316610; CAX72341.1; -; mRNA.
DR   MEROPS; A01.009; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; -; 1.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033144; Cathepsin_D.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   PANTHER; PTHR13683:SF230; PTHR13683:SF230; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   2: Evidence at transcript level;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454,
KW   ECO:0000256|SAAS:SAAS00478160};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454,
KW   ECO:0000256|SAAS:SAAS00478138, ECO:0000313|EMBL:CAX72341.1};
KW   Protease {ECO:0000256|RuleBase:RU000454,
KW   ECO:0000256|SAAS:SAAS00478033, ECO:0000313|EMBL:CAX72341.1}.
SQ   SEQUENCE   262 AA;  28687 MW;  B83065B5693118A1 CRC64;
     MAKFDGILGM AYPSLAVGGV TPVFVNMIKQ GVVDSPVFSF YLSRNITNVL GGELMIGGID
     DKYYTGEINY VNLTEKSYWL FKMDNLTISD LSICTDGCQA IADTGTSMIA GPTDEVKQIN
     QKLGATHLPG GIYTVSCDVI NNLPSIDFVI NGKHMTLEPT DYIMKVSKLG SEICLTGFIG
     MDLPRKKLWI LGDVFIGKFY TIFDMGKNRV GFAKAVKPDS SYHHTKVYSP MLRLFPAQSI
     PKVAPKSPNG VFAFSKLLHD AN
//