ID   Q5C141_SCHJA            Unreviewed;       262 AA.
AC   Q5C141;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   03-OCT-2012, entry version 40.
DE   SubName: Full=Cathepsin D (Lysosomal aspartyl protease);
DE            EC=3.4.23.5;
GN   Name=ctsd;
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Han Z.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16617374; DOI=10.1371/journal.ppat.0020029;
RA   Liu F., Lu J., Hu W., Wang S.-Y., Cui S.-J., Chi M., Yan Q.,
RA   Wang X.-R., Song H.-D., Xu X.-N., Wang J.-J., Zhang X.-L., Zhang X.,
RA   Wang Z.-Q., Xue C.-L., Brindley P.J., McManus D.P., Yang P.-Y.,
RA   Feng Z., Chen Z., Han Z.-G.;
RT   "New perspectives on host-parasite interplay by comparative
RT   transcriptomic and proteomic analyses of Schistosoma japonicum.";
RL   PLoS Pathog. 2:268-281(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui;
RX   DOI=10.1038/nature08140;
RA   Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J.,
RA   McManus D.P., Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G.,
RA   Chen Z.;
RT   "The Schistosoma japonicum genome reveals features of host-parasite
RT   interplay.";
RL   Nature 460:345-351(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui;
RA   Gang L.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY810745; AAX26634.1; -; mRNA.
DR   EMBL; FN316610; CAX72341.1; -; mRNA.
DR   ProteinModelPortal; Q5C141; -.
DR   MEROPS; A01.009; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; G3DSA:2.40.70.10; Pept_Aspartc_cat; 1.
DR   InterPro; IPR001461; Peptidase_A1.
DR   InterPro; IPR021109; Peptidase_aspartic.
DR   InterPro; IPR001969; Peptidase_aspartic_AS.
DR   InterPro; IPR009007; Peptidase_aspartic_catalytic.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Pept_Aspartic; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
PE   2: Evidence at transcript level;
KW   Aspartyl protease; Hydrolase; Protease.
SQ   SEQUENCE   262 AA;  28687 MW;  B83065B5693118A1 CRC64;
     MAKFDGILGM AYPSLAVGGV TPVFVNMIKQ GVVDSPVFSF YLSRNITNVL GGELMIGGID
     DKYYTGEINY VNLTEKSYWL FKMDNLTISD LSICTDGCQA IADTGTSMIA GPTDEVKQIN
     QKLGATHLPG GIYTVSCDVI NNLPSIDFVI NGKHMTLEPT DYIMKVSKLG SEICLTGFIG
     MDLPRKKLWI LGDVFIGKFY TIFDMGKNRV GFAKAVKPDS SYHHTKVYSP MLRLFPAQSI
     PKVAPKSPNG VFAFSKLLHD AN
//