ID   Q5BL52_XENTR            Unreviewed;       578 AA.
AC   Q5BL52;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   05-DEC-2018, entry version 122.
DE   SubName: Full=Matrix metallopeptidase 14 (Membrane-inserted) {ECO:0000313|EMBL:AAH90600.1};
GN   Name=mmp14 {ECO:0000313|EMBL:AAH90600.1,
GN   ECO:0000313|Xenbase:XB-GENE-485643};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH90600.1};
RN   [1] {ECO:0000313|EMBL:AAH90600.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH90600.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS01067066};
CC   -!- SIMILARITY: Belongs to the peptidase M10A family.
CC       {ECO:0000256|SAAS:SAAS00542437}.
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DR   EMBL; BC090600; AAH90600.1; -; mRNA.
DR   RefSeq; NP_001025559.1; NM_001030388.1.
DR   UniGene; Str.25328; -.
DR   ProteinModelPortal; Q5BL52; -.
DR   MEROPS; M10.014; -.
DR   GeneID; 594950; -.
DR   KEGG; xtr:594950; -.
DR   CTD; 4323; -.
DR   Xenbase; XB-GENE-485643; mmp14.
DR   eggNOG; KOG1565; Eukaryota.
DR   eggNOG; ENOG410XQ5D; LUCA.
DR   HOGENOM; HOG000217928; -.
DR   HOVERGEN; HBG052484; -.
DR   KO; K07763; -.
DR   OrthoDB; EOG091G03DP; -.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0001503; P:ossification; IBA:GO_Central.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:InterPro.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:InterPro.
DR   GO; GO:0031638; P:zymogen activation; IBA:GO_Central.
DR   CDD; cd00094; HX; 1.
DR   CDD; cd04278; ZnMc_MMP; 1.
DR   Gene3D; 2.110.10.10; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR000585; Hemopexin-like_dom.
DR   InterPro; IPR036375; Hemopexin-like_dom_sf.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR018486; Hemopexin_CS.
DR   InterPro; IPR033739; M10A_MMP.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR028693; MMP14.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR021805; Pept_M10A_metallopeptidase_C.
DR   InterPro; IPR021158; Pept_M10A_Zn_BS.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   PANTHER; PTHR10201:SF24; PTHR10201:SF24; 1.
DR   Pfam; PF11857; DUF3377; 1.
DR   Pfam; PF00045; Hemopexin; 4.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   PIRSF; PIRSF001191; Peptidase_M10A_matrix; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SMART; SM00120; HX; 4.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   PROSITE; PS00546; CYSTEINE_SWITCH; 1.
DR   PROSITE; PS00024; HEMOPEXIN; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 4.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|SAAS:SAAS00710469};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00734812};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00973787};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|SAAS:SAAS00473618};
KW   Protease {ECO:0000256|SAAS:SAAS00973825};
KW   Repeat {ECO:0000256|SAAS:SAAS00878391};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|SAAS:SAAS00973802}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    578       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004253765.
FT   TRANSMEM    535    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      106    276       ZnMc. {ECO:0000259|SMART:SM00235}.
FT   REPEAT      315    363       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      364    409       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      411    459       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      460    507       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   ACT_SITE    231    231       {ECO:0000256|PIRSR:PIRSR001191-1}.
SQ   SEQUENCE   578 AA;  65838 MW;  F7BC45C7EA1FA96E CRC64;
     MEPVRAAWIC LFLCSVCSSS SAKFSPEAWL QQYGYLPPGD LRTHTLRSPQ SMNAAISAMQ
     KFYGLKVTGS FDSETERAMK RPRCGVPDKF GAEIKANVRR KRYAIQGLKW QHKDITFCIQ
     NYTPKIGEYS TYEAIRRAFK VWESVTPLRF REVRYVDIKD GYTKHADIML FFAEGFHGDS
     TPFDGEGGFL AHAYFPGPGI GGDTHFDSAE PWTARNDDLD GNDLFLVAVH ELGHALGLEH
     SNDPSAIMAP FYQWMDTQNF QLPDDDRRGI QQLYGPNHGE GLPTRAPRPT RAPRPTQTQR
     PDDTPHDPNP PTYGPDICQG NFDTIAMLRG EMFVFKERWF WRVRHKRVMD GYPMPIGQFW
     RGLPSSINSA YERKDGKFVF FKGDKHWVFD EAILEPGYPK TLKELGRGLP SDRIDAALYW
     MPNGKTYFFR GTKYYRFNEE MRAVDPDYPK PVNVWEGIPD SIKGAFMGSD GAFTYFYKGN
     KYWKFNNQLL KTESGYPKSV LVDWMGCSTA RQPDDDVDRE VVIIEVDEAS GGVSAAAIVV
     PVLLLLCVLA LGLAVVLFRQ CGTPKRLLYW QRSLLDKV
//