ID Q5APD4_CANAL PRELIMINARY; PRT; 513 AA. AC Q5APD4; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 04-APR-2006, entry version 12. DE Potential cyclopropane-fatty-acyl-phospholipid synthase. GN Name=CFA1; ORFNames=CaO19.12294, CaO19.4831; OS Candida albicans SC5314. OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; mitosporic Saccharomycetales; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., RA Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., RA Davis R.W., Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. CC -!- FUNCTION: Catalyzes the methyl transfer from S-adenosyl-methionine CC to the C-24 of zymosterol to form fecosterol (By similarity). CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 5-alpha-cholesta- CC 8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5- CC alpha-cholest-8-en-3-beta-ol. CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + phospholipid CC olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid CC cyclopropane fatty acid. CC -!- PATHWAY: Ergosterol biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACQ01000002; EAL04623.1; -; Genomic_DNA. DR EMBL; AACQ01000001; EAL04819.1; -; Genomic_DNA. DR GO; GO:0008825; F:cyclopropane-fatty-acyl-phospholipid syntha...; IEA. DR GO; GO:0008610; P:lipid biosynthesis; IEA. DR InterPro; IPR003333; CMAS. DR InterPro; IPR001601; Methyltransf. DR InterPro; IPR000051; SAM_bd. DR Pfam; PF02353; CMAS; 1. KW Methyltransferase; Steroid biosynthesis; Sterol biosynthesis; KW Transferase. SQ SEQUENCE 513 AA; 58777 MW; 3CA020873BCD76B4 CRC64; MLDDVAFIKT PAAKKQPPAS NECGVWTTDS PAIHNAPLPA DGPGSTSFSN TILFSILALV PGYITYKLGL GFKTWVFFFL ILAIPILMAY WSIMSTFSPR INEKVKYPNR PISYYLEFHT PELKAKYETS NGGKGSKIPI ETFQELYFDG KVSFKGDCLD VLEYKHDWAS FRFTLGLFRF FLLGMIPEVI FHSQSQDEEQ VRDHYDRGDD FYTWFLGPRM IYTSGVISDI TREETLEELQ DNKLTVMADK IDLKKGDHVL DIGCGWGTWT TFASSKYGAN VTGITLGRNQ TKWGNTLLKE YGIPSDQSRI VCCDYRDAPK SSKPSGKYDK ITSVEMAEHV GIRRLTAYLE QCRDALEDDG LLFLQYSGLR KNWQYEDLEW GLFMNKYIFP GADASTPLSF FASCMESVGF EIVSVDNIGV HYSATLWRWY RNWIGNKDKV VNKYGVKWYR IWEFFLGSSV VASRNGTATC YQFICRKNIN SYRRIDYVPQ QKGLQGPVQE GTKWAKEFTN FYD //