ID MON1_CANAL Reviewed; 565 AA. AC Q5A723; A0A1D8PSL7; DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 26-APR-2005, sequence version 1. DT 24-JAN-2024, entry version 87. DE RecName: Full=Vacuolar fusion protein MON1; GN Name=MON1; OrderedLocusNames=CAALFM_CR03960CA; ORFNames=CaO19.8109; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [2] RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- FUNCTION: In complex with CCZ1, is required for multiple vacuole CC delivery pathways including the cytoplasm to vacuole transport (Cvt), CC autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the CC fusion of vesicles with the vacuole, through its regulation of the CC SNARE complex during the coordinated priming and docking stages of CC fusion, and particularly at the stage of tethering/docking. CC {ECO:0000250|UniProtKB:P53129}. CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar CC compartment membrane {ECO:0000250}; Peripheral membrane protein CC {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane CC protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP017630; AOW31134.1; -; Genomic_DNA. DR RefSeq; XP_717342.2; XM_712249.2. DR AlphaFoldDB; Q5A723; -. DR SMR; Q5A723; -. DR STRING; 237561.Q5A723; -. DR EnsemblFungi; CR_03960C_A-T; CR_03960C_A-T-p1; CR_03960C_A. DR GeneID; 3640963; -. DR KEGG; cal:CAALFM_CR03960CA; -. DR CGD; CAL0000177089; orf19.8109. DR VEuPathDB; FungiDB:CR_03960C_A; -. DR eggNOG; KOG0997; Eukaryota. DR HOGENOM; CLU_025637_0_0_1; -. DR InParanoid; Q5A723; -. DR OMA; IHNSSRP; -. DR OrthoDB; 73361at2759; -. DR Proteomes; UP000000559; Chromosome R. DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central. DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central. DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell. DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW. DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central. DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro. DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1. DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2. DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3. DR InterPro; IPR004353; Mon1. DR PANTHER; PTHR13027; SAND PROTEIN-RELATED; 1. DR PANTHER; PTHR13027:SF7; VACUOLAR FUSION PROTEIN MON1 HOMOLOG; 1. DR Pfam; PF19036; Fuz_longin_1; 1. DR Pfam; PF19037; Fuz_longin_2; 1. DR Pfam; PF19038; Fuz_longin_3; 1. DR PRINTS; PR01546; YEAST73DUF. PE 3: Inferred from homology; KW Autophagy; Endosome; Membrane; Protein transport; Reference proteome; KW Transport; Vacuole. FT CHAIN 1..565 FT /note="Vacuolar fusion protein MON1" FT /id="PRO_0000278856" FT REGION 1..37 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 565 AA; 64521 MW; 0DB9DBEABB1513FE CRC64; MSFPKTLNVP DKSSLLVPQT TKASATGPTT AVSYETASSE IRSIRESPYL PSSPVDSQQF DGRSIISTSG MSEYIADLND LPSIRHDINP TSIKTGGTGS RSFKFSNCFQ TLDSELSNMD FFTKYISISK GDDKAQFNNK LKHFFIFSSA GKPIYSMNGS DDIVIGYMGI LTTIVSSFQE NFNQELQVLE LGQGLKIVAV NKSPIILISI SKLSFETVES VHLQLDTLYC YLIGILSKSV IDKHFNNRLN YDLRRILSPL DFENLDELCL NLTYGIPNTS DRTQDSTFGL YTSQVLLPLS RESVKIRHTL RSKLNSIVNT NNEDVLFTIL LSGNGKILNY LHPKQHNLPN KDLNMLLFII HSLLKNQSQQ DEDLWLPLCM PTFNDHGFLY VFVRQWQDLV LMLISGSKNS FDALKLSANE ICTKLNNKQE LAVKLINELS IPLSIEVPFV FKHFIYKDIR LNQFVMSELP THEFSSFQFL KCYNELKVSQ AKIIKHDNNL NYKKLTYLQD RDITGFMLMD KYYEFYCIIE RSSEQETITS KKLIQISSQI IRWCKKNHAR LFVTI //