ID Q59EI3_HUMAN Unreviewed; 444 AA. AC Q59EI3; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 10-MAY-2017, entry version 71. DE SubName: Full=Branched chain keto acid dehydrogenase E1, alpha polypeptide variant {ECO:0000313|EMBL:BAD93065.1}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD93065.1}; RN [1] {ECO:0000313|EMBL:BAD93065.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAD93065.1}; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., RA Ohara O., Nagase T., Kikuno R.F.; RT "Homo sapiens protein coding cDNA."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB209828; BAD93065.1; -; mRNA. DR RefSeq; NP_001158255.1; NM_001164783.1. DR RefSeq; NP_001158255.1; NM_001164783.1. DR RefSeq; NP_001158255.1; NM_001164783.1. DR UniGene; Hs.433307; -. DR ProteinModelPortal; Q59EI3; -. DR STRING; 9606.ENSP00000269980; -. DR MaxQB; Q59EI3; -. DR PaxDb; Q59EI3; -. DR PeptideAtlas; Q59EI3; -. DR PRIDE; Q59EI3; -. DR GeneID; 593; -. DR CTD; 593; -. DR PharmGKB; PA25297; -. DR eggNOG; KOG1182; Eukaryota. DR eggNOG; COG1071; LUCA. DR HOVERGEN; HBG002459; -. DR GenomeRNAi; 593; -. DR Bgee; ENSG00000248098; -. DR Genevisible; Q59EI3; HS. DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:InterPro. DR GO; GO:0003826; F:alpha-ketoacid dehydrogenase activity; IEA:InterPro. DR GO; GO:0009083; P:branched-chain amino acid catabolic process; IEA:InterPro. DR InterPro; IPR034616; BCKDH_E1-a. DR InterPro; IPR001017; DH_E1. DR InterPro; IPR029061; THDP-binding. DR PANTHER; PTHR43380:SF1; PTHR43380:SF1; 1. DR Pfam; PF00676; E1_dh; 1. DR SUPFAM; SSF52518; SSF52518; 1. PE 2: Evidence at transcript level; FT DOMAIN 106 404 E1_dh. {ECO:0000259|Pfam:PF00676}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAD93065.1}. SQ SEQUENCE 444 AA; 50400 MW; C5A54AFF6AB9BF87 CRC64; MAVAIAAARV WRLNRGLSQA ALLLLRQPGA RGLARSHPPR QQQQFSSLDD KPQFPGASAE FIDKLEFIQP NVISGIPIYR VMDRQGQIIN PSEDPHLPKE KVLKLYKSMT LLNTMDRILY ESQRQGRISF YMTNYGEEGT HVGSAAALDN TDLVFGQYRE AGVLMYRDYP LELFMAQCYG NISDLGKGRQ MPVHYGCKER HFVTISSPLA TQIPQAVGAA YAAKRANANR VVICYFGEGA ASEGDAHAGF NFAATLECPI IFFCRNNGYA ISTPTSEQYR GDGIARGPGY GIMSIRVDGN DVFAVYNATK EARRRAVAEN QPFLIEAMTY RIGHHSTSDD SSAYRSVDEV NYWDKQDHPI SRLRHYLLSQ GWWDEEQEKA WRKQSRRKVM EAFEQAERKP KPNPNLLFSD VYQEMPAQLR KQQESLARHL QTYGEHYPLD HFDK //