ID Q59EB3_HUMAN Unreviewed; 712 AA. AC Q59EB3; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 24-JUL-2024, entry version 130. DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD93135.1}; RN [1] {ECO:0000313|EMBL:BAD93135.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Aorta endothelial cell {ECO:0000313|EMBL:BAD93135.1}; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., RA Ohara O., Nagase T., Kikuno R.F.; RT "Homo sapiens protein coding cDNA."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB209898; BAD93135.1; -; mRNA. DR AlphaFoldDB; Q59EB3; -. DR DrugBank; DB08111; 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol. DR PeptideAtlas; Q59EB3; -. DR GO; GO:0009925; C:basal plasma membrane; IEA:TreeGrafter. DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0005008; F:hepatocyte growth factor receptor activity; IEA:TreeGrafter. DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter. DR GO; GO:0001889; P:liver development; IEA:TreeGrafter. DR GO; GO:0030182; P:neuron differentiation; IEA:TreeGrafter. DR GO; GO:0031016; P:pancreas development; IEA:TreeGrafter. DR CDD; cd00603; IPT_PCSR; 1. DR CDD; cd01181; IPT_plexin_repeat3; 1. DR CDD; cd05058; PTKc_Met_Ron; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 2. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR050122; RTK. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR PANTHER; PTHR24416:SF483; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1. DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01833; TIG; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00429; IPT; 2. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF81296; E set domains; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Kinase {ECO:0000256|ARBA:ARBA00023137}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transferase {ECO:0000256|ARBA:ARBA00023137}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}. FT TRANSMEM 253..277 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 400..667 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 432 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAD93135.1" SQ SEQUENCE 712 AA; 79524 MW; 80C2711BA6B2DC04 CRC64; LDYLNSGNSR HISIGGKTCT LKSVSNSILE CYTPAQTIST EFAVKLKIDL ANRETSIFSY REDPIVYEIH PTKSFISGGS TITGVGKNLN SVSVPRMVIN VHEAGRNFTV ACQHRSNSEI ICCTTPSLQQ LNLQLPLKTK AFFMLDGILS KYFDLIYVHN PVFKPFEKPV MISMGNENVL EIKGNDIDPE AVKGEVLKVG NKSCENIHLH SEAVLCTVPN DLLKLNSELN IEWKQAISST VLGKVIVQPD QNFTGLIAGV VSISTALLLL LGFFLWLKKR KQIKDLGSEL VRYDARVHTP HLDRLVSARS VSPTTEMVSN ESVDYRATFP EDQFPNSSQN GSCRQVQYPL TDMSPILTSG DSDISSPLLQ NTVHIDLSAL NPELVQAVQH VVIGPSSLIV HFNEVIGRGH FGCVYHGTLL DNDGKKIHCA VKSLNRITDI GEVSQFLTEG IIMKDFSHPN VLSLLGICLR SEGSPLVVLP YMKHGDLRNF IRNETHNPTV KDLIGFGLQV AKGMKYLASK KFVHRDLAAR NCMLDEKFTV KVADFGLARD MYDKEYYSVH NKTGAKLPVK WMALESLQTQ KFTTKSDVWS FGVLLWELMT RGAPPYPDVN TFDITVYLLQ GRRLLQPEYC PDPLYEVMLK CWHPKAEMRP SFSELVSRIS AIFSTFIGEH YVHVNATYVN VKCVAPYPSL LSSEDNADDE VDTRPASFWE TS //