ID MYOC_FELCA Reviewed; 490 AA. AC Q594P2; DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot. DT 26-APR-2005, sequence version 1. DT 10-JUN-2008, entry version 19. DE Myocilin precursor. GN Name=MYOC; OS Felis silvestris catus (Cat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Fautsch M.P., Vrabel A.M., Johnson D.H.; RT "Characterization of the domestic cat myocilin cDNA."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May participate in the obstruction of fluid outflow in CC the trabecular meshwork (By similarity). CC -!- SUBUNIT: Homodimer. Interacts with OLFM3 (By similarity). CC -!- SUBCELLULAR LOCATION: Rough endoplasmic reticulum (By similarity). CC Secreted (By similarity). Cell projection, cilium (By similarity). CC Note=Located preferentially in the ciliary rootlet and basal body CC of the connecting cilium of photoreceptor cells, and in the rough CC endoplasmic reticulum. Also secreted (By similarity). CC -!- SIMILARITY: Contains 1 olfactomedin-like domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY566569; AAS68633.1; -; mRNA. DR HOVERGEN; Q594P2; -. DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell. DR InterPro; IPR003924; GPCR_2_latrophilin. DR InterPro; IPR003112; Olfac_like. DR Pfam; PF02191; OLF; 1. DR PRINTS; PR01444; LATROPHILIN. DR SMART; SM00284; OLF; 1. DR PROSITE; PS51132; OLF; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Coiled coil; Endoplasmic reticulum; KW Glycoprotein; Secreted; Signal. FT SIGNAL 1 18 Potential. FT CHAIN 19 490 Myocilin. FT /FTId=PRO_0000041830. FT DOMAIN 230 489 Olfactomedin-like. FT COILED 52 169 Potential. FT MOTIF 488 490 Microbody targeting signal (Potential). FT CARBOHYD 43 43 N-linked (GlcNAc...) (Potential). FT DISULFID 231 419 By similarity. SQ SEQUENCE 490 AA; 55306 MW; B7FC900365FF83A5 CRC64; MPATQLLLLA CLVWGLGART AQLRKANDRS GRCQYTFSVA SPNESSCPEQ GQAMSAIQDL QRDSSAQRAD LESTKARLRS LESLVHQLTL DEAAGPSATQ EGLQRELGAL RREREQLESQ NRELEASYSN LLRDKSALEE EKRRLREENE DLARRLDSSS QEVARLRRGQ CPQARGTPQD VPSGSREVSK WNVETVNFQE LKSELTEVPA SRILKESPSG HPRSEEGDPG CGELVWVGEP LTLRRAETIT GKYGVWMRDP KPAYPYTQET TWRIDTVGTD IRQVFEYDLS SQFLQGYPSK VHVLPRPLES TGAVVYWGSL YFQGAESRTV IRYELNTETV KAEKEIPGAG YHGQFPYSWG GYTDIDLAVD ETGLWVIYST QEAKGAIVLS KLNPESLELE RTWETNIRKQ SVANAFIICG RLYTVSSYSA PDATINFAYD TGTGRSRALT VPFKNRYKYS SMVDYNPLEK KLFAWDNFNM VTYDLRLSEM //