ID Q59289 PRELIMINARY; PRT; 659 AA. AC Q59289; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-NOV-1998 (TrEMBLrel. 08, Last annotation update) DE HEPARINASE III PROTEIN PRECURSOR (EC 4.2.2.8) (HEPARITIN-SULFATE DE LYASE) (HEPARIN-SULFATE ELIMINASE). GN HEPC. OS Pedobacter heparinus (Flavobacterium heparinum). OC Bacteria; CFB group; Sphingobacteria; Sphingobacteriaceae; Pedobacter. OX NCBI_TaxID=984; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96316388; PubMed=8702264; RA Su H., Blain F., Musil R.A., Zimmermann J.J., Gu K., Bennett D.C.; RT "Isolation and expression in Escherichia coli of hepB and hepC, genes RT coding for the glycosaminoglycan-degrading enzymes heparinase II and RT heparinase III, respectively, from Flavobacterium heparinum."; RL Appl. Environ. Microbiol. 62:2723-2734(1996). RN [2] RP SEQUENCE FROM N.A. RA Tkalec A.L.; RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: ELIMINATION OF SULFATE; APPEARS TO ACT ON CC LINKAGES BETWEEN N-ACETYL-D- GLUCOSAMINE AND URONATE. PRODUCT IS CC AN UNSATURATED SUGAR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U27586; AAB18278.1; -. KW Signal; Lyase. FT SIGNAL 1 24 POTENTIAL. FT CHAIN 25 659 SQ SEQUENCE 659 AA; 75806 MW; B73EDF10A1256FE2 CRC64; MTTKIFKRII VFAVIALSSG NILAQSSSIT RKDFDHINLE YSGLEKVNKA VAAGNYDDAA KALLAYYREK SKAREPDFSN AEKPADIRQP IDKVTREMAD KALVHQFQPH KGYGYFDYGK DINWQMWPVK DNEVRWQLHR VKWWQAMALV YHATGDEKYA REWVYQYSDW ARKNPLGLSQ DNDKFVWRPL EVSDRVQSLP PTFSLFVNSP AFTPAFLMEF LNSYHQQADY LSTHYAEQGN HRLFEAQRNL FAGVSFPEFK DSPRWRQTGI SVLNTEIKKQ VYADGMQFEL SPIYHVAAID IFLKAYGSAK RVNLEKEFPQ SYVQTVENMI MALISISLPD YNTPMFGDSW ITDKNFRMAQ FASWARVFPA NQAIKYFATD GKQGKAPNFL SKALSNAGFY TFRSGWDKNA TVMVLKASPP GEFHAQPDNG TFELFIKGRN FTPDAGVFVY SGDEAIMKLR NWYRQTRIHS TLTLDNQNMV ITKARQNKWE TGNNLDVLTY TNPSYPNLDH QRSVLFINKK YFLVIDRAIG EATGNLGVHW QLKEDSNPVF DKTKNRVYTT YRDGNNLMIQ SLNADRTSLN EEEGKVSYVY NKELKRPAFV FEKPKKNAGT QNFVSIVYPY DGQKAPEISI RENKGNDFEK GKLNLTLTIN GKQQLVLVP //