ID RIB7_METJA Reviewed; 224 AA. AC Q58085; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 22-JUL-2008, entry version 52. DE RecName: Full=Putative 5-amino-6-(5-phosphoribosylamino)uracil reductase; DE EC=1.1.1.193; DE AltName: Full=HTP reductase; GN OrderedLocusNames=MJ0671; OS Methanocaldococcus jannaschii (Methanococcus jannaschii). OC Archaea; Euryarchaeota; Methanococci; Methanococcales; OC Methanocaldococcaceae; Methanocaldococcus. OX NCBI_TaxID=2190; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440; RX MEDLINE=96337999; PubMed=8688087; RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.; RT "Complete genome sequence of the methanogenic archaeon, Methanococcus RT jannaschii."; RL Science 273:1058-1073(1996). CC -!- CATALYTIC ACTIVITY: 5-amino-6-(5-phosphoribitylamino)uracil + CC NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH. CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 6,7- CC dimethyl-8-(1-D-ribityl)lumazine from GTP: step 3/4. CC -!- SIMILARITY: Belongs to the HTP reductase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L77117; AAB98665.1; -; Genomic_DNA. DR PIR; G64383; G64383. DR RefSeq; NP_247655.1; -. DR PDB; 2AZN; X-ray; 2.70 A; A/B/C/D/E/F=6-224. DR PDBsum; 2AZN; -. DR GeneID; 1451537; -. DR GenomeReviews; L77117_GR; MJ0671. DR KEGG; mja:MJ0671; -. DR NMPDR; fig|243232.1.peg.692; -. DR TIGR; MJ0671; -. DR HOGENOM; Q58085; -. DR BioCyc; MJAN243232:MJ_0671-MON; -. DR InterPro; IPR004794; Eubact_ribD. DR InterPro; IPR006401; Rib_reduct_arc. DR InterPro; IPR011549; RibD_C. DR InterPro; IPR002734; RibDG_C. DR PANTHER; PTHR11079:SF10; Eubact_ribD; 1. DR Pfam; PF01872; RibD_C; 1. DR TIGRFAMs; TIGR01508; rib_reduct_arch; 1. DR TIGRFAMs; TIGR00227; ribD_Cterm; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; NADP; Oxidoreductase; KW Riboflavin biosynthesis. FT CHAIN 1 224 Putative 5-amino-6-(5- FT phosphoribosylamino)uracil reductase. FT /FTId=PRO_0000135944. FT STRAND 10 18 FT STRAND 22 24 FT HELIX 35 46 FT STRAND 48 54 FT HELIX 55 61 FT STRAND 77 81 FT HELIX 92 94 FT STRAND 100 104 FT HELIX 110 121 FT STRAND 125 128 FT STRAND 131 133 FT HELIX 136 145 FT STRAND 150 155 FT HELIX 157 165 FT STRAND 171 180 FT STRAND 188 190 FT HELIX 198 200 FT STRAND 201 212 FT STRAND 215 222 SQ SEQUENCE 224 AA; 25037 MW; 4D8C15CE291E89D8 CRC64; MVMVMEKKPY IISNVGMTLD GKLATINNDS RISCEEDLIR VHKIRANVDG IMVGIGTVLK DDPRLTVHKI KSDRNPVRIV VDSKLRVPLN ARVLNKDAKT IIATTEDTNE EKEKKIKILE DMGVEVVKCG RGKVDLKKLM DILYDKGIKS ILLEGGGTLN WGMFKEGLVD EVSVYIAPKI FGGKEAPTYV DGEGFKTVDE CVKLELKNFY RLGEGIVLEF KVKK //