ID RIB7_METJA Reviewed; 224 AA. AC Q58085; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 03-APR-2007, entry version 39. DE Putative 5-amino-6-(5-phosphoribosylamino)uracil reductase DE (EC 1.1.1.193) (HTP reductase). GN OrderedLocusNames=MJ0671; OS Methanococcus jannaschii. OC Archaea; Euryarchaeota; Methanococci; Methanococcales; OC Methanocaldococcaceae; Methanocaldococcus. OX NCBI_TaxID=2190; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440; RX MEDLINE=96337999; PubMed=8688087; RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.; RT "Complete genome sequence of the methanogenic archaeon, Methanococcus RT jannaschii."; RL Science 273:1058-1073(1996). CC -!- CATALYTIC ACTIVITY: 5-amino-6-(5-phosphoribitylamino)uracil + CC NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH. CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 6,7- CC dimethyl-8-(1-D-ribityl)lumazine from GTP: step 3/4. CC -!- SIMILARITY: Belongs to the HTP reductase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L77117; AAB98665.1; -; Genomic_DNA. DR PIR; G64383; G64383. DR GenomeReviews; L77117_GR; MJ0671. DR KEGG; mja:MJ0671; -. DR TIGR; MJ0671; -. DR BioCyc; MJAN243232:MJ0671-MONOMER; -. DR InterPro; IPR006401; Rib_reduct_arc. DR InterPro; IPR011549; RibD_C. DR InterPro; IPR002734; RibDG_C. DR Pfam; PF01872; RibD_C; 1. DR TIGRFAMs; TIGR01508; rib_reduct_arch; 1. DR TIGRFAMs; TIGR00227; ribD_Cterm; 1. KW Complete proteome; Hypothetical protein; NADP; Oxidoreductase; KW Riboflavin biosynthesis. FT CHAIN 1 224 Putative 5-amino-6-(5- FT phosphoribosylamino)uracil reductase. FT /FTId=PRO_0000135944. SQ SEQUENCE 224 AA; 25037 MW; 4D8C15CE291E89D8 CRC64; MVMVMEKKPY IISNVGMTLD GKLATINNDS RISCEEDLIR VHKIRANVDG IMVGIGTVLK DDPRLTVHKI KSDRNPVRIV VDSKLRVPLN ARVLNKDAKT IIATTEDTNE EKEKKIKILE DMGVEVVKCG RGKVDLKKLM DILYDKGIKS ILLEGGGTLN WGMFKEGLVD EVSVYIAPKI FGGKEAPTYV DGEGFKTVDE CVKLELKNFY RLGEGIVLEF KVKK //