ID Q571K9_MOUSE Unreviewed; 1048 AA. AC Q571K9; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 12-APR-2017, entry version 87. DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133}; DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133}; DE Flags: Fragment; GN Name=Plcb3 {ECO:0000313|MGI:MGI:104778}; GN Synonyms=mKIAA4098 {ECO:0000313|EMBL:BAD90365.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAD90365.1}; RN [1] {ECO:0000313|EMBL:BAD90365.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Embryonic tail {ECO:0000313|EMBL:BAD90365.1}; RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Koseki H., Hiraoka S., RA Saga Y., Nagase T., Ohara O., Koga H.; RT "Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene. RT The Complete Nucleotide Sequences of Mouse KIAA-homologous cDNAs RT Identified by Screening of Terminal sequences of cDNA Clones Randomly RT Sampled from Size-Fractionated Libraries.."; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5- CC bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + CC diacylglycerol. {ECO:0000256|RuleBase:RU361133}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK220180; BAD90365.1; -; mRNA. DR UniGene; Mm.273204; -. DR ProteinModelPortal; Q571K9; -. DR STRING; 10090.ENSMUSP00000025912; -. DR PaxDb; Q571K9; -. DR PeptideAtlas; Q571K9; -. DR PRIDE; Q571K9; -. DR MGI; MGI:104778; Plcb3. DR eggNOG; KOG0169; Eukaryota. DR eggNOG; ENOG410XPSW; LUCA. DR HOVERGEN; HBG053609; -. DR ChiTaRS; Plcb3; mouse. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC. DR GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. DR Gene3D; 1.10.238.10; -; 1. DR Gene3D; 2.60.40.150; -; 1. DR Gene3D; 3.20.20.190; -; 1. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR011993; PH_dom-like. DR InterPro; IPR001192; PI-PLC_fam. DR InterPro; IPR016280; PLC-beta. DR InterPro; IPR028390; PLC-beta3. DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl. DR InterPro; IPR015359; PLC_EF-hand-like. DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom. DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y. DR PANTHER; PTHR10336; PTHR10336; 1. DR PANTHER; PTHR10336:SF137; PTHR10336:SF137; 1. DR Pfam; PF00168; C2; 1. DR Pfam; PF09279; EF-hand_like; 1. DR Pfam; PF00388; PI-PLC-X; 1. DR Pfam; PF00387; PI-PLC-Y; 1. DR PIRSF; PIRSF000956; PLC-beta; 1. DR PRINTS; PR00390; PHPHLIPASEC. DR SMART; SM00239; C2; 1. DR SMART; SM00148; PLCXc; 1. DR SMART; SM00149; PLCYc; 1. DR SUPFAM; SSF47473; SSF47473; 1. DR SUPFAM; SSF49562; SSF49562; 1. DR SUPFAM; SSF50729; SSF50729; 1. DR SUPFAM; SSF51695; SSF51695; 2. DR PROSITE; PS50004; C2; 1. DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1. DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|RuleBase:RU361133}; KW Lipid degradation {ECO:0000256|RuleBase:RU361133}; KW Lipid metabolism {ECO:0000256|RuleBase:RU361133}; KW Transducer {ECO:0000256|SAAS:SAAS00123199}. FT DOMAIN 353 503 PI-PLC X-box. {ECO:0000259|PROSITE: FT PS50007}. FT DOMAIN 626 742 PI-PLC Y-box. {ECO:0000259|PROSITE: FT PS50008}. FT DOMAIN 749 846 C2. {ECO:0000259|PROSITE:PS50004}. FT ACT_SITE 367 367 {ECO:0000256|PIRSR:PIRSR000956-1}. FT ACT_SITE 414 414 {ECO:0000256|PIRSR:PIRSR000956-1}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAD90365.1}. SQ SEQUENCE 1048 AA; 117162 MW; E7B8433C7C3AA3FE CRC64; RRGARAGRAG ACGESSGTVG SRRGSVGPRA APGLAMAGAR PGVHALQLEP PTVVETLRRG SKFIKWDEEA SSRNLVTLRV DPNGFFLYWT GPNMEVDTLD ISSIRDTRTG RYARLPKDPK IREVLGFGGP DTRLEEKLMT VVAGPDPVNT TFLNFMAVQD DTVKVWSEEL FKLAMNILAQ NASRNTFLRK AYTKLKLQVN QDGRIPVKNI LKMFSADKKR VETALESCGL NFNRSESIRP DEFPLEIFER FLNKLCLRPD IDKILLEIGA KGKPYLTLEQ LMDFINQKQR DPRLNEVLYP PLRSSQARLL IEKYETNKQF LERDQMSMEG FSRYLGGEEN GILPLEALDL SMDMTQPLSA YFINSSHNTY LTAGQLAGPS SVEMYRQALL WGCRCVELDV WKGRPPEEEP FITHGFTMTT EVPLRDVLEA IAEAAFKTSP YPVILSFENH VDSAKQQAKM AEYCRSIFGD ALLIDPLDKY PLSAGIPLPS PQDLMGRILV KNKKRHRPST GVPDSSVRKR PLEQSNSALS ESSAATEPSS PQLGSPSSDS CPGLSNGEEV GLEKTSLEPQ KSLGEESLSR EPNVPMPDRD REDEEEDEEE EETTDPKKPT TDEGTASSEV NATEEMSTLV NYVEPVKFKS FEAARKRNKC FEMSSFVETK AMEQLTKSPM EFVEYNKQQL SRIYPKGTRV DSSNYMPQLF WNVGCQLVAL NFQTLDLPMQ LNAGVFEYNG RSGYLLKPEF MRRPDKSFDP FTEVIVDGIV ANALRVKVIS GQFLSDKKVG IYVEVDMFGL PVDTRRKYRT RTSQGNSFNP VWDEEPFDFP KVVLPTLASL RIAAFEEGGK FVGHRILPVS AIRSGYHYVC LRNEANQPLC LPALLIYTEA SDYIPDDHQD YAEALINPIK HVSLMDQRAK QLAALIGESE AQASTETYQE TPCQQPGSQL PSNPTPNPLD ASPRWPPGPT TSSTSSSLSS PGQRDDLIAS ILSEVTPTPL EELRSHKAMV KLRSRQDRDL RELHKKHQRK AVALTRRLLD GLAQARAEGK CRPSPSAL //