ID   POLS3_MOUSE             Reviewed;         552 AA.
AC   Q571E5; Q8CFX9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-NOV-2008, entry version 25.
DE   RecName: Full=Polyserase-3;
DE            EC=3.4.21.-;
DE   AltName: Full=Polyserine protease 3;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreatic islet;
RA   Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene.
RT   The complete nucleotide sequences of mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-552.
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In vitro can degrade the fibrinogen alpha chain of as
CC       well as pro-urokinase-type plasminogen activator (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 2 peptidase S1 domains.
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DR   EMBL; AK220244; BAD90169.1; ALT_INIT; mRNA.
DR   EMBL; BC039632; AAH39632.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001074737.1; -.
DR   UniGene; Mm.438786; -.
DR   MEROPS; S01.374; -.
DR   MEROPS; S01.375; -.
DR   Ensembl; ENSMUSG00000044139; Mus musculus.
DR   GeneID; 330657; -.
DR   KEGG; mmu:330657; -.
DR   MGI; MGI:2652890; BC039632.
DR   HOGENOM; Q571E5; -.
DR   HOVERGEN; Q571E5; -.
DR   NextBio; 399489; -.
DR   CleanEx; MM_BC039632; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 2.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 2.
DR   PROSITE; PS50240; TRYPSIN_DOM; 2.
DR   PROSITE; PS00134; TRYPSIN_HIS; 2.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protease; Repeat; Secreted; Serine protease; Signal.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    552       Polyserase-3.
FT                                /FTId=PRO_0000316764.
FT   DOMAIN       24    273       Peptidase S1 1.
FT   DOMAIN      294    525       Peptidase S1 2.
FT   ACT_SITE     77     77       Charge relay system (By similarity).
FT   ACT_SITE    128    128       Charge relay system (By similarity).
FT   ACT_SITE    224    224       Charge relay system (By similarity).
FT   ACT_SITE    341    341       Charge relay system (By similarity).
FT   ACT_SITE    382    382       Charge relay system (By similarity).
FT   ACT_SITE    477    477       Charge relay system (By similarity).
FT   DISULFID     62     78       By similarity.
FT   DISULFID    158    230       By similarity.
FT   DISULFID    187    209       By similarity.
FT   DISULFID    220    249       By similarity.
FT   DISULFID    326    342       By similarity.
FT   DISULFID    443    463       By similarity.
FT   DISULFID    473    501       By similarity.
SQ   SEQUENCE   552 AA;  58974 MW;  4E605F7BA1AB8A91 CRC64;
     MRQSWRPELL IVGAVVVIEG LQAAQRACGQ RGPGPPEPQE GNTLPGEWPW QASVRRQGVH
     ICSGSLVADT WVLTAAHCFE KMATAELSSW SVVLGSLKQE GQSPGAEEVG VAALQLPKAY
     NHYSQGSDLA LLQLTHPTVQ TTLCLPQPTY HFPFGASCWA TGWDQNTSDV SRTLRNLRLR
     LISRPTCNCL YNRLHQRLLS NPARPGMLCG GAQPGEQGPC QGDSGGPVMC REPDGHWVQV
     GIISFTSKCA QEDTPVLLTD MAVHSSWLQA HVHEAAFLVQ APGVVKMSDE NSCVACGSLR
     SAGPQAGALS QWPWDARLKH HGKLACGGAL VSEVVVLTAA HCFIGRQTLE EWSVGLGAGP
     EEWGLKQLIL HGAYTHPEGG YDVAFLLLAQ PVTLGPGLRP LCLPYADHHL PDGEHGWVLG
     LTQKAGINYP QTVPVTVLGP MACSRQHAAP GGTGIPILPG MVCTTVVGEP PHCEGLSGAP
     LVHEIRGTWF LVGLHSFGDT CQSSAKPAVF AALSAYEDWI SNLDWQVYFA EEPEPEAETG
     SCLVNSSQPA SC
//