ID Q571C2_MOUSE Unreviewed; 141 AA. AC Q571C2; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 13-FEB-2019, entry version 66. DE RecName: Full=Molybdopterin molybdenumtransferase {ECO:0000256|RuleBase:RU365090}; DE EC=2.10.1.1 {ECO:0000256|RuleBase:RU365090}; DE Includes: DE RecName: Full=Molybdopterin adenylyltransferase {ECO:0000256|RuleBase:RU365090}; DE Short=MPT adenylyltransferase {ECO:0000256|RuleBase:RU365090}; DE EC=2.7.7.75 {ECO:0000256|RuleBase:RU365090}; DE AltName: Full=Domain G {ECO:0000256|RuleBase:RU365090}; DE Includes: DE RecName: Full=Molybdopterin molybdenumtransferase {ECO:0000256|RuleBase:RU365090}; DE Short=MPT Mo-transferase {ECO:0000256|RuleBase:RU365090}; DE EC=2.10.1.1 {ECO:0000256|RuleBase:RU365090}; DE AltName: Full=Domain E {ECO:0000256|RuleBase:RU365090}; DE Flags: Fragment; GN Name=Gphn {ECO:0000313|MGI:MGI:109602}; GN Synonyms=mKIAA1385 {ECO:0000313|EMBL:BAD90192.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAD90192.1}; RN [1] {ECO:0000313|EMBL:BAD90192.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Adult pancreatic islet {ECO:0000313|EMBL:BAD90192.1}; RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., RA Nagase T., Ohara O., Koga H.; RT "Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene. RT The Complete Nucleotide Sequences of Mouse KIAA-homologous cDNAs RT Identified by Screening of Terminal sequences of cDNA Clones Randomly RT Sampled from Size-Fractionated Libraries.."; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes two steps in the biosynthesis of the CC molybdenum cofactor. In the first step, molybdopterin is CC adenylated. Subsequently, molybdate is inserted into adenylated CC molybdopterin and AMP is released. CC {ECO:0000256|RuleBase:RU365090}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H(+) + molybdopterin = adenylyl-molybdopterin + CC diphosphate; Xref=Rhea:RHEA:31331, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58698, CC ChEBI:CHEBI:62727; Evidence={ECO:0000256|RuleBase:RU365090}; CC -!- CATALYTIC ACTIVITY: CC Reaction=adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + CC Mo-molybdopterin; Xref=Rhea:RHEA:35047, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:36264, ChEBI:CHEBI:62727, CC ChEBI:CHEBI:71302, ChEBI:CHEBI:456215; CC Evidence={ECO:0000256|RuleBase:RU365090}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU365090}; CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. CC {ECO:0000256|RuleBase:RU365090}. CC -!- SIMILARITY: Belongs to the MoeA family. CC {ECO:0000256|RuleBase:RU365090}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK220267; BAD90192.1; -; mRNA. DR UniGene; Mm.341742; -. DR UniGene; Mm.363753; -. DR UniGene; Mm.453131; -. DR PeptideAtlas; Q571C2; -. DR MGI; MGI:109602; Gphn. DR eggNOG; KOG2371; Eukaryota. DR eggNOG; COG0303; LUCA. DR eggNOG; COG0521; LUCA. DR UniPathway; UPA00344; -. DR ChiTaRS; Gphn; mouse. DR GO; GO:0032324; P:molybdopterin cofactor biosynthetic process; IEA:InterPro. DR Gene3D; 2.40.340.10; -; 1. DR Gene3D; 3.40.980.10; -; 1. DR InterPro; IPR036425; MoaB/Mog-like_dom_sf. DR InterPro; IPR038987; MoeA-like. DR InterPro; IPR005111; MoeA_C_domain_IV. DR InterPro; IPR036688; MoeA_C_domain_IV_sf. DR PANTHER; PTHR10192; PTHR10192; 1. DR Pfam; PF03454; MoeA_C; 1. DR SUPFAM; SSF53218; SSF53218; 1. DR SUPFAM; SSF63867; SSF63867; 1. PE 2: Evidence at transcript level; KW Magnesium {ECO:0000256|RuleBase:RU365090}; KW Metal-binding {ECO:0000256|RuleBase:RU365090}; KW Molybdenum {ECO:0000256|RuleBase:RU365090}; KW Molybdenum cofactor biosynthesis {ECO:0000256|RuleBase:RU365090}; KW Transferase {ECO:0000256|RuleBase:RU365090}. FT DOMAIN 63 137 MoeA_C. {ECO:0000259|Pfam:PF03454}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAD90192.1}. SQ SEQUENCE 141 AA; 15827 MW; 3BBE81039D6DBB00 CRC64; FGRVFMKPGL PTTFATLDID GVRKIIFALP GNPVSAVVTC NLFVVPALRK MHGILDPRPT IIKARLSCDV KLDPRPEYHR CILTWHHQEP LPWAQSTGNQ MSSRLMSMRS ANGLLMLPPK TEQYVELHKG EVVDVMVIGR L //