ID ADCC_DICDI Reviewed; 654 AA. AC Q55CH0; DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2005, sequence version 1. DT 24-JAN-2024, entry version 109. DE RecName: Full=Arrestin domain-containing protein C; GN Name=adcC; ORFNames=DDB_G0271022; OS Dictyostelium discoideum (Social amoeba). OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). RN [2] RP IDENTIFICATION. RX PubMed=17659086; DOI=10.1186/gb-2007-8-7-r144; RA Sawai S., Guan X.-J., Kuspa A., Cox E.C.; RT "High-throughput analysis of spatio-temporal dynamics in Dictyostelium."; RL Genome Biol. 8:R144.1-R144.15(2007). CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI02000005; EAL72861.1; -; Genomic_DNA. DR RefSeq; XP_646511.1; XM_641419.1. DR AlphaFoldDB; Q55CH0; -. DR SMR; Q55CH0; -. DR STRING; 44689.Q55CH0; -. DR PaxDb; 44689-DDB0267092; -. DR EnsemblProtists; EAL72861; EAL72861; DDB_G0271022. DR GeneID; 8617472; -. DR KEGG; ddi:DDB_G0271022; -. DR dictyBase; DDB_G0271022; adcC. DR eggNOG; KOG3780; Eukaryota. DR HOGENOM; CLU_443082_0_0_1; -. DR InParanoid; Q55CH0; -. DR OMA; IVQPDPK; -. DR PRO; PR:Q55CH0; -. DR Proteomes; UP000002195; Chromosome 1. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:dictyBase. DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase. DR GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IGI:dictyBase. DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase. DR GO; GO:0031210; F:phosphatidylcholine binding; IDA:dictyBase. DR GO; GO:0001786; F:phosphatidylserine binding; IDA:dictyBase. DR GO; GO:0031152; P:aggregation involved in sorocarp development; IGI:dictyBase. DR GO; GO:0002031; P:G protein-coupled receptor internalization; IGI:dictyBase. DR GO; GO:0015031; P:protein transport; IBA:GO_Central. DR GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:dictyBase. DR CDD; cd00030; C2; 1. DR Gene3D; 2.60.40.640; -; 2. DR Gene3D; 2.60.40.150; C2 domain; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1. DR InterPro; IPR014752; Arrestin-like_C. DR InterPro; IPR011021; Arrestin-like_N. DR InterPro; IPR011022; Arrestin_C-like. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR035892; C2_domain_sf. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR013761; SAM/pointed_sf. DR PANTHER; PTHR11188; ARRESTIN DOMAIN CONTAINING PROTEIN; 1. DR PANTHER; PTHR11188:SF17; LD44267P; 1. DR Pfam; PF02752; Arrestin_C; 1. DR Pfam; PF00339; Arrestin_N; 1. DR Pfam; PF00168; C2; 1. DR SMART; SM01017; Arrestin_C; 1. DR SMART; SM00239; C2; 1. DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1. DR SUPFAM; SSF81296; E set domains; 2. DR SUPFAM; SSF47769; SAM/Pointed domain; 1. DR PROSITE; PS50004; C2; 1. PE 3: Inferred from homology; KW Coiled coil; Reference proteome. FT CHAIN 1..654 FT /note="Arrestin domain-containing protein C" FT /id="PRO_0000363156" FT DOMAIN 1..105 FT /note="C2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041" FT COILED 616..647 FT /evidence="ECO:0000255" SQ SEQUENCE 654 AA; 74207 MW; 0D7C4D3CBBD02ECA CRC64; MTQRSLKINI IEGKDLKGLD SGGVSDCYVK FKCGPISAKT EVIKKSTSPI WNYMINIGNV EENTLLQFEC FDWERIGNNR TMGKTQAFVS DLSSGAKRNL MDQWLRLDTK GFIRISYEFT PPYPLETEST NSPNLSVVGN GSSSSSSLMY NPTPVYFKPI FLPTIPSETI NNNKSTTCHF LIPGSVYQTR PFVCGEFVNC SLVLNVFEAR IVVRSLNLSF SGSITYKGKK QRKLVNDYRD LLLGFTGGVP VPNNNGNNNL TSNKVVLERG KHVFPFQFFI DKTCKSTVNL TDYKVNYYLS FHADIVNQPD ISASQEIKVV NLEDTVYKQT ISPINAQTSK SPLTGGNISI SCKSVKNSFY PGEEIELEVE VNNSSKKKIK NVDIQLNKVE YDGTDVTGTS YQLLTMTKKF YPKIKQNTAC KQMVVIELPS TTQCVGLIHS IAETKMIRVE YHLLVNLDIP SCVDLRLKLP ITIVQPDPKF ETLPNPLTEI GNLPRYVKDW SIKNFHSWVL FKKQCPDVMA LNPEFYQYNL SGSDLMQLPT ETLYSIFKGA GPRTQELVND LQSQIFEIKL VRNFLKELQL SNLIDYFEKQ TITWDILLQL NYNEIFSITD ITIGDAKRIF LKIQQIQSER QKQQEQQEQQ VVSNLEAVSL QKSE //