ID DRKB_DICDI Reviewed; 690 AA. AC Q54H45; DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2005, sequence version 1. DT 20-JUN-2018, entry version 89. DE RecName: Full=Probable serine/threonine-protein kinase drkB; DE EC=2.7.11.1; DE AltName: Full=Receptor-like kinase 2; DE AltName: Full=Receptor-like kinase B; DE AltName: Full=Vesicle-associated receptor tyrosine kinase-like protein 2; DE Flags: Precursor; GN Name=drkB; Synonyms=rk2; ORFNames=DDB_G0289709; OS Dictyostelium discoideum (Slime mold). OC Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., RA Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr CC protein kinase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI02000148; EAL62566.1; -; Genomic_DNA. DR RefSeq; XP_636073.1; XM_630981.1. DR ProteinModelPortal; Q54H45; -. DR SMR; Q54H45; -. DR STRING; 44689.DDB0229954; -. DR PaxDb; Q54H45; -. DR PRIDE; Q54H45; -. DR EnsemblProtists; EAL62566; EAL62566; DDB_G0289709. DR GeneID; 8627283; -. DR KEGG; ddi:DDB_G0289709; -. DR dictyBase; DDB_G0289709; drkB. DR eggNOG; KOG0192; Eukaryota. DR eggNOG; COG0515; LUCA. DR InParanoid; Q54H45; -. DR OMA; SPDICIC; -. DR PRO; PR:Q54H45; -. DR Proteomes; UP000002195; Chromosome 5. DR Proteomes; UP000002195; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Glycoprotein; Kinase; Membrane; KW Nucleotide-binding; Reference proteome; KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 690 Probable serine/threonine-protein kinase FT drkB. FT /FTId=PRO_0000358882. FT TRANSMEM 346 366 Helical. {ECO:0000255}. FT DOMAIN 391 644 Protein kinase. {ECO:0000255|PROSITE- FT ProRule:PRU00159}. FT NP_BIND 397 405 ATP. {ECO:0000255|PROSITE- FT ProRule:PRU00159}. FT COMPBIAS 60 67 Poly-Ser. FT COMPBIAS 73 86 Poly-Ser. FT COMPBIAS 269 330 Thr-rich. FT COMPBIAS 655 674 Poly-Asn. FT COMPBIAS 677 680 Poly-Asn. FT ACT_SITE 514 514 Proton acceptor. {ECO:0000255|PROSITE- FT ProRule:PRU00159, ECO:0000255|PROSITE- FT ProRule:PRU10027}. FT BINDING 418 418 ATP. {ECO:0000255|PROSITE- FT ProRule:PRU00159}. FT CARBOHYD 134 134 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 180 180 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 220 220 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 250 250 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. SQ SEQUENCE 690 AA; 76041 MW; 5A0A8373D8D4DFE5 CRC64; MKVQIVFFSI TVFIFVLFLL SVESNTKIKI VPSFLENSNE IEDLYINLDS DSKSSEHTTS SSSSSNSKNK GDSSSSSSNS GSSSNSIISG DSNSKDAPTT SSDSLSPATP IPTDGLLSAS TYVTFTGGKV LCENITFCPN GYMYSSDYAC NYDIVQNDPA THRGDWNDGI KMFEDPLPKN TTIDQVEGIS FTISGAVGCQ VTSSATTLEF YIQDLLVLTN TTSRYDICTC GSCYVTFGTE VYKYNMLGYN ITGENKFQIQ VSVNSMCATT IGITLYYKPP TITPTPTITP TPTITPTPTI TPTVTPTATP STTPSTTPTT TPSTPTPTPT KSPYSGALSP QVKKYIIIAS SITGGLLISI FSFVFIRKRL NSKRSGYTQI KDGKDIDTQQ IKIGVRIGKG NFGEVYLGTW RGSQVAVKKL PAHNINENIL KEFHREINLM KNLRHPNVIQ FLGSCLISPD ICICTEYMPR GSLYSILHNE KIKISWSLVK RMMIDAAKGI IYLHGSTPVI LHRDLKSHNL LVDENWKVKV ADFGLSTIEQ QGATMTACGT PCWTSPEVLR SQRYTEKADV YSFGIILWEC ATRQDPYFGI PPFQVIFAVG REGMRPPTPK YGPPKYIQLL KDCLNENPSQ RPTMEQCLEI LESIETKGFD DIPVNNNNNN NSNNNENNNE NNNNSDNNNN DINYSNRVIN //