ID Q54FY3_DICDI Unreviewed; 494 AA. AC Q54FY3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 19-JAN-2022, entry version 106. DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:EAL62100.1}; GN Name=hydA {ECO:0000313|EMBL:EAL62100.1}; GN ORFNames=DDB0201650 {ECO:0000313|EMBL:EAL62100.1}; OS Dictyostelium discoideum (Slime mold). OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL62100.1, ECO:0000313|Proteomes:UP000002195}; RN [1] {ECO:0000313|EMBL:EAL62100.1, ECO:0000313|Proteomes:UP000002195} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4 {ECO:0000313|EMBL:EAL62100.1, RC ECO:0000313|Proteomes:UP000002195}; RX PubMed=15875012; DOI=10.1038/nature03481; RG The Dictyostelium discoideum Sequencing Consortium; RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R., RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N., RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N., RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D., RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A., RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S., RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G., RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L., RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H., RA Noegel A.A., Barrell B., Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. CC {ECO:0000256|RuleBase:RU003345}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EAL62100.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI01000235; EAL62100.1; -; Genomic_DNA. DR RefSeq; XP_635634.1; XM_630542.1. DR STRING; 44689.DDB0201650; -. DR PaxDb; Q54FY3; -. DR GeneID; 8627706; -. DR KEGG; ddi:DDB_G0290479; -. DR dictyBase; DDB_G0290479; hydA. DR eggNOG; KOG2450; Eukaryota. DR HOGENOM; CLU_005391_0_1_1; -. DR InParanoid; Q54FY3; -. DR OMA; AGLWTEN; -. DR PhylomeDB; Q54FY3; -. DR Reactome; R-DDI-196757; Metabolism of folate and pterines. DR Reactome; R-DDI-380612; Metabolism of serotonin. DR Reactome; R-DDI-5365859; RA biosynthesis pathway. DR Reactome; R-DDI-70350; Fructose catabolism. DR Reactome; R-DDI-71384; Ethanol oxidation. DR Proteomes; UP000002195; Unassembled WGS sequence. DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; ISS:dictyBase. DR Gene3D; 3.40.309.10; -; 1. DR Gene3D; 3.40.605.10; -; 1. DR InterPro; IPR016161; Ald_DH/histidinol_DH. DR InterPro; IPR016163; Ald_DH_C. DR InterPro; IPR029510; Ald_DH_CS_GLU. DR InterPro; IPR016162; Ald_DH_N. DR InterPro; IPR015590; Aldehyde_DH_dom. DR Pfam; PF00171; Aldedh; 1. DR SUPFAM; SSF53720; SSF53720; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. PE 3: Inferred from homology; KW Oxidoreductase {ECO:0000256|RuleBase:RU003345}; KW Reference proteome {ECO:0000313|Proteomes:UP000002195}. FT DOMAIN 17..482 FT /note="Aldedh" FT /evidence="ECO:0000259|Pfam:PF00171" FT ACT_SITE 256 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007" SQ SEQUENCE 494 AA; 54284 MW; A5F7FA052BA49D4B CRC64; MSKVQLPNTK LFINNEWVES VSGKKFKTFN PVNEELICEV SEGDKADVDI AVKAAREALE NGEWSKMTSE DRGRIILKFA DLIEKHKDNL AQLETLDNGK PLTASKGYDI TQSEKTLRYF GGWADKIQGK TIPISNEYTS ITRHEPIGVV ALIVAWNYPC MLLCWKLGPA LAAGCTIVAK PSEFTPLTAL YLCELIKEAG FPPGVFNLVN GFGATVGSAL SHHMDIDKIS FTGSTITGRL IMEGAAKSNL KPVTLELGGK SPNIFFNDCD VNHIAQCAKD YVFANSMQSC CAPSRFFVQE NIYEAFLQIF TENIKLLKVG DPNVNGTNLG PLVSKQQHDR VLGYIQKGKE EGATCHLGGG NYHHADGKGY FVQPTIFTNV TDDMTICKEE IFGPVVVILP FKTVDEVIKR ANNTTYGLAA GVWTKDISLA LNVSNKLKSG SVWINEYYSI MPSIPFGGYK QSGIGRDLSE YAIQSYLSVK AVTIAHKTLH AQQQ //