ID   XPO7_DICDI              Reviewed;        1007 AA.
AC   Q54DN3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   24-JUL-2024, entry version 84.
DE   RecName: Full=Exportin-7;
DE            Short=Exp7;
GN   Name=xpo7; Synonyms=Ranbp7; ORFNames=DDB_G0291986;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC       substrate specificity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Nucleus, nuclear pore complex {ECO:0000250}. Note=Shuttles between the
CC       nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AAFI02000187; EAL61349.2; -; Genomic_DNA.
DR   RefSeq; XP_629839.2; XM_629837.3.
DR   AlphaFoldDB; Q54DN3; -.
DR   SMR; Q54DN3; -.
DR   STRING; 44689.Q54DN3; -.
DR   PaxDb; 44689-DDB0233670; -.
DR   ABCD; Q54DN3; 2 sequenced antibodies.
DR   EnsemblProtists; EAL61349; EAL61349; DDB_G0291986.
DR   GeneID; 8628520; -.
DR   KEGG; ddi:DDB_G0291986; -.
DR   dictyBase; DDB_G0291986; xpo7.
DR   VEuPathDB; AmoebaDB:DDB_G0291986; -.
DR   eggNOG; KOG1410; Eukaryota.
DR   HOGENOM; CLU_005409_1_1_1; -.
DR   InParanoid; Q54DN3; -.
DR   OMA; ANYHEFC; -.
DR   PhylomeDB; Q54DN3; -.
DR   PRO; PR:Q54DN3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; ISS:dictyBase.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR044189; XPO4/7-like.
DR   PANTHER; PTHR12596; EXPORTIN 4,7-RELATED; 1.
DR   PANTHER; PTHR12596:SF2; EXPORTIN-7 ISOFORM X1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..1007
FT                   /note="Exportin-7"
FT                   /id="PRO_0000328523"
SQ   SEQUENCE   1007 AA;  117160 MW;  73F18C53057CB4A3 CRC64;
     MSIQSEQDFF KFEELCKDFY LKPEETIKID DILHQYFLNP NFLIEYKQIL SFTKNSYVVA
     QVIRGLIKCV TSFWTSLTPN QKNDMSKSIE HHCIGLRILK DIISEFNEYI GEHLTVLQHR
     NISISLRDNI LLDIFCISLE SLNYALANSM DEKFKSIKEL ALDLSYSCLS FDFIKTTSID
     SSEEILTVQI PSQWKSTFDE NNPLELFFKI YKQYHSTKSL ECILQIVSIR RSFFTTEDER
     VKFLASIVQY TTEILKSNIG FNEPNNHLVF SRVIERLKTN YHLNNLVTVV GYNDWISNLS
     TFTIDTLKNP QFSPNSIYFL LTLWAKLVSS IIYVKGDPSK TYLEKYSPII MESFINSKID
     NSYSDEEDEH LMDYEKMVEI LEGIPHLGRI TYQATCRQII LLFDSISSKF LNETNPTQLE
     VYERQCAWLV YIIGCLILGR TSINSSEEHD KIDGELSVRV FILIGYNDKK LSAESNTQYQ
     YRTSRISLEL SFIYFMQNFR RIYIGENSIS SSKIYQRISE LSGPTDHTSV LFSIVQKIGF
     NFKYWAENDE IIKKSLDMFW ESVNGHSTSK MLIDNKITKD ILKTHSSQVF PFLEKNSNPR
     NRTSLYKTIG KLLFTDENMG FFDEFIAPFD DTIKHLLNIS TPEQFRTEEI KRKVIGLLRD
     LRGIITSANS KRSYLLFFEW IHLNFSEVLI KIINVWVDSP EVTTSLLKFI SEFVFNRQSR
     LIFDSSSANG FIIFRDTSKI LVSYASLILK ANISKQDLYK FKIKGIQTSM LLFTRCLVGG
     YCNFGVFELY GDPSFTSAID YIFQLCLSVS LDELMSFPKA SKAYVTMLEA LCLGHTLSII
     QLNQQYFIHI MKSLHRCLDS QDVTMSSSSC TSIEKIITVC YYHLKKKNSQ CLQAIHQNFF
     SNSNILYEII DKIISIIIYE DNFNQFMFSK LLLTCIIFHQ DTFTTLKQKY IHSFNSQCPE
     KVEKAFVQLM ENTLDNLETK NKDKFTSNVS IFRKEMKLIS SSTGRYL
//