ID   Q546I7_HUMAN            Unreviewed;       366 AA.
AC   Q546I7;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   13-NOV-2007, entry version 30.
DE   MHC class I antigen.
GN   Name=HLA-C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Cox S.T.;
RT   "Full genomic sequence alignments for HLA-B and -C.";
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system (By similarity).
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
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DR   EMBL; AJ420244; CAD12429.1; -; Genomic_DNA.
DR   EMBL; AJ420246; CAD12431.1; -; Genomic_DNA.
DR   UniGene; Hs.449621; -.
DR   UniGene; Hs.654404; -.
DR   UniGene; Hs.656020; -.
DR   UniGene; Hs.77961; -.
DR   SMR; Q546I7; 26-302.
DR   Ensembl; ENSG00000206452; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:InterPro.
DR   GO; GO:0002474; P:antigen processing and presentation of pept...; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Gene3D; G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Immune response; MHC I; Membrane; Transmembrane.
SQ   SEQUENCE   366 AA;  40773 MW;  2A84D41389A0486A CRC64;
     MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG YVDDTQFVQF
     DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHTLQ
     RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARTAEQL
     RAYLEGTCVE WLRRYLENGK KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP
     SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES
     LIACKA
//