ID Q543A9_MOUSE Unreviewed; 362 AA. AC Q543A9; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 30-NOV-2016, entry version 102. DE SubName: Full=Prostaglandin E receptor 2 (Subtype EP2) {ECO:0000313|EMBL:EDL20685.1}; GN Name=Ptger2 {ECO:0000313|EMBL:EDL20685.1, ECO:0000313|MGI:MGI:97794}; GN ORFNames=mCG_2021 {ECO:0000313|EMBL:EDL20685.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Oviduct {ECO:0000313|EMBL:BAC35664.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:EDL20685.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL20685.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [8] {ECO:0000313|EMBL:BAE23391.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23391.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [10] {ECO:0000313|EMBL:BAC35664.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35664.1}; RC TISSUE=Bone {ECO:0000313|EMBL:BAE23391.1}, and Oviduct RC {ECO:0000313|EMBL:BAC35664.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [11] {ECO:0000313|EMBL:EDL20685.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL20685.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK054132; BAC35664.1; -; mRNA. DR EMBL; AK137515; BAE23391.1; -; mRNA. DR EMBL; CH466605; EDL20685.1; -; Genomic_DNA. DR RefSeq; NP_032990.1; NM_008964.4. DR UniGene; Mm.4630; -. DR STRING; 10090.ENSMUSP00000038483; -. DR GeneID; 19217; -. DR KEGG; mmu:19217; -. DR CTD; 5732; -. DR MGI; MGI:97794; Ptger2. DR eggNOG; KOG3656; Eukaryota. DR eggNOG; ENOG410XRW9; LUCA. DR HOVERGEN; HBG003074; -. DR KO; K04259; -. DR OMA; NDSWPED; -. DR OrthoDB; EOG091G0F07; -. DR Bgee; ENSMUSG00000037759; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004957; F:prostaglandin E receptor activity; IEA:Ensembl. DR GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Ensembl. DR GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR008365; Prostanoid_rcpt. DR InterPro; IPR001923; Prostglndn_EP2_rcpt. DR PANTHER; PTHR11866; PTHR11866; 1. DR PANTHER; PTHR11866:SF8; PTHR11866:SF8; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00581; PRSTNOIDEP2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:EDL20685.1}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 27 47 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 67 92 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 112 133 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 154 176 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 196 224 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 286 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 298 318 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 39 315 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 362 AA; 40479 MW; A79FCEE8B6771F44 CRC64; MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS SASKQTDLCG QL //