ID Q541P3_MOUSE Unreviewed; 249 AA. AC Q541P3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 20-JAN-2016, entry version 99. DE SubName: Full=Brain-derived neurotrophic factor {ECO:0000313|EMBL:AAL27784.1, ECO:0000313|Ensembl:ENSMUSP00000106672}; DE SubName: Full=Brain-derived neurotrophic factor BDNF1 {ECO:0000313|EMBL:AAL27785.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF2B {ECO:0000313|EMBL:AAL27787.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF6A {ECO:0000313|EMBL:AAO74602.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant I {ECO:0000313|EMBL:ABM30155.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIA {ECO:0000313|EMBL:ABM30156.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIC {ECO:0000313|EMBL:ABM30158.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant III {ECO:0000313|EMBL:ABM30167.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IV {ECO:0000313|EMBL:ABM30159.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant VIII {ECO:0000313|EMBL:ABM30170.1}; GN Name=Bdnf {ECO:0000313|EMBL:AAL27785.1, GN ECO:0000313|Ensembl:ENSMUSP00000106672, ECO:0000313|MGI:MGI:88145}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAO74602.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO74602.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RX PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004; RA Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.; RT "Rodent BDNF genes, novel promoters, novel splice variants, and RT regulation by cocaine."; RL Brain Res. 1067:1-12(2006). RN [4] {ECO:0000313|EMBL:ABM30155.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 x CBA {ECO:0000313|EMBL:ABM30155.1}; RX PubMed=17149751; DOI=10.1002/jnr.21139; RA Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.; RT "Mouse and rat BDNF gene structure and expression revisited."; RL J. Neurosci. Res. 85:525-535(2007). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000106672, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106672, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000106672} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106672}; RG Ensembl; RL Submitted (AUG-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL732477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY057907; AAL27784.1; -; Genomic_DNA. DR EMBL; AY057908; AAL27785.1; -; mRNA. DR EMBL; AY057909; AAL27786.1; -; mRNA. DR EMBL; AY057910; AAL27787.1; -; mRNA. DR EMBL; AY057911; AAL27788.1; -; mRNA. DR EMBL; AY057912; AAL27789.1; -; mRNA. DR EMBL; AY057913; AAL27790.1; -; mRNA. DR EMBL; AY057914; AAL27791.1; -; mRNA. DR EMBL; AY231131; AAO74602.1; -; mRNA. DR EMBL; AY231132; AAO74603.1; -; mRNA. DR EMBL; EF125669; ABM30155.1; -; mRNA. DR EMBL; EF125670; ABM30156.1; -; mRNA. DR EMBL; EF125671; ABM30157.1; -; mRNA. DR EMBL; EF125672; ABM30158.1; -; mRNA. DR EMBL; EF125673; ABM30159.1; -; mRNA. DR EMBL; EF125674; ABM30160.1; -; mRNA. DR EMBL; EF125681; ABM30167.1; -; mRNA. DR EMBL; EF125682; ABM30168.1; -; mRNA. DR EMBL; EF125683; ABM30169.1; -; mRNA. DR EMBL; EF125684; ABM30170.1; -; mRNA. DR EMBL; EF125685; ABM30171.1; -; mRNA. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_031566.4; NM_007540.4. DR UniGene; Mm.1442; -. DR STRING; 10090.ENSMUSP00000057989; -. DR Ensembl; ENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482. DR Ensembl; ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482. DR GeneID; 12064; -. DR KEGG; mmu:12064; -. DR CTD; 627; -. DR MGI; MGI:88145; Bdnf. DR eggNOG; ENOG410IH7X; Eukaryota. DR eggNOG; ENOG410XRPH; LUCA. DR GeneTree; ENSGT00390000007725; -. DR HOVERGEN; HBG006494; -. DR KO; K04355; -. DR NextBio; 280377; -. DR Proteomes; UP000000589; Chromosome 2. DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. DR GO; GO:0030141; C:secretory granule; IDA:MGI. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0005169; F:neurotrophin TRKB receptor binding; IBA:GO_Central. DR GO; GO:0048675; P:axon extension; IDA:MGI. DR GO; GO:0007411; P:axon guidance; IMP:MGI. DR GO; GO:0007412; P:axon target recognition; IMP:MGI. DR GO; GO:0001662; P:behavioral fear response; IMP:MGI. DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central. DR GO; GO:0048668; P:collateral sprouting; ISO:MGI. DR GO; GO:0016358; P:dendrite development; IMP:MGI. DR GO; GO:0097484; P:dendrite extension; IDA:MGI. DR GO; GO:0042596; P:fear response; IMP:MGI. DR GO; GO:0007631; P:feeding behavior; IMP:MGI. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IDA:MGI. DR GO; GO:0014047; P:glutamate secretion; IPI:MGI. DR GO; GO:0060080; P:inhibitory postsynaptic potential; IMP:MGI. DR GO; GO:0048839; P:inner ear development; IMP:MGI. DR GO; GO:0007611; P:learning or memory; IMP:MGI. DR GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI. DR GO; GO:0060548; P:negative regulation of cell death; IMP:MGI. DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IDA:MGI. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI. DR GO; GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IDA:MGI. DR GO; GO:0021675; P:nerve development; IMP:MGI. DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central. DR GO; GO:0008038; P:neuron recognition; IMP:MGI. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IDA:MGI. DR GO; GO:2000324; P:positive regulation of glucocorticoid receptor signaling pathway; ISO:MGI. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:MGI. DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:MGI. DR GO; GO:0048670; P:regulation of collateral sprouting; IGI:MGI. DR GO; GO:0019222; P:regulation of metabolic process; IMP:MGI. DR GO; GO:0043523; P:regulation of neuron apoptotic process; IDA:MGI. DR GO; GO:0046668; P:regulation of retinal cell programmed cell death; IDA:MGI. DR GO; GO:0048167; P:regulation of synaptic plasticity; IDA:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0007416; P:synapse assembly; ISO:MGI. DR GO; GO:0061193; P:taste bud development; IMP:MGI. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR GO; GO:0001657; P:ureteric bud development; IDA:MGI. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00022131}; KW Growth factor {ECO:0000256|SAAS:SAAS00160138}; KW Proteomics identification {ECO:0000213|MaxQB:Q541P3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005933464. FT DOMAIN 135 242 NGF. {ECO:0000259|SMART:SM00140}. SQ SEQUENCE 249 AA; 28123 MW; 90CE1F16BB235C97 CRC64; MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR //