ID Q541P3_MOUSE Unreviewed; 249 AA. AC Q541P3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 04-MAR-2015, entry version 89. DE SubName: Full=Brain-derived neurotrophic factor {ECO:0000313|EMBL:AAL27784.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF2C {ECO:0000313|EMBL:AAL27788.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF3 {ECO:0000313|EMBL:AAL27789.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF4 {ECO:0000313|EMBL:AAL27790.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF6A {ECO:0000313|EMBL:AAO74602.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF6B {ECO:0000313|EMBL:AAO74603.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant I {ECO:0000313|EMBL:ABM30155.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIC {ECO:0000313|EMBL:ABM30158.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IV {ECO:0000313|EMBL:ABM30159.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant V {ECO:0000313|EMBL:ABM30168.1}; GN Name=Bdnf {ECO:0000313|EMBL:AAL27785.1, ECO:0000313|MGI:MGI:88145}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAO74602.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO74602.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RX PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004; RA Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.; RT "Rodent BDNF genes, novel promoters, novel splice variants, and RT regulation by cocaine."; RL Brain Res. 1067:1-12(2006). RN [4] {ECO:0000313|EMBL:ABM30155.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 x CBA {ECO:0000313|EMBL:ABM30155.1}; RX PubMed=17149751; DOI=10.1002/jnr.21139; RA Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.; RT "Mouse and rat BDNF gene structure and expression revisited."; RL J. Neurosci. Res. 85:525-535(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY057907; AAL27784.1; -; Genomic_DNA. DR EMBL; AY057908; AAL27785.1; -; mRNA. DR EMBL; AY057909; AAL27786.1; -; mRNA. DR EMBL; AY057910; AAL27787.1; -; mRNA. DR EMBL; AY057911; AAL27788.1; -; mRNA. DR EMBL; AY057912; AAL27789.1; -; mRNA. DR EMBL; AY057913; AAL27790.1; -; mRNA. DR EMBL; AY057914; AAL27791.1; -; mRNA. DR EMBL; AY231131; AAO74602.1; -; mRNA. DR EMBL; AY231132; AAO74603.1; -; mRNA. DR EMBL; EF125669; ABM30155.1; -; mRNA. DR EMBL; EF125670; ABM30156.1; -; mRNA. DR EMBL; EF125671; ABM30157.1; -; mRNA. DR EMBL; EF125672; ABM30158.1; -; mRNA. DR EMBL; EF125673; ABM30159.1; -; mRNA. DR EMBL; EF125674; ABM30160.1; -; mRNA. DR EMBL; EF125681; ABM30167.1; -; mRNA. DR EMBL; EF125682; ABM30168.1; -; mRNA. DR EMBL; EF125683; ABM30169.1; -; mRNA. DR EMBL; EF125684; ABM30170.1; -; mRNA. DR EMBL; EF125685; ABM30171.1; -; mRNA. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_031566.4; NM_007540.4. DR UniGene; Mm.1442; -. DR GeneID; 12064; -. DR KEGG; mmu:12064; -. DR CTD; 627; -. DR MGI; MGI:88145; Bdnf. DR GeneTree; ENSGT00390000007725; -. DR HOVERGEN; HBG006494; -. DR KO; K04355; -. DR NextBio; 280377; -. DR Genevestigator; Q541P3; -. DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. DR GO; GO:0030425; C:dendrite; IEA:Ensembl. DR GO; GO:0005576; C:extracellular region; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0030061; C:mitochondrial crista; IEA:Ensembl. DR GO; GO:0043204; C:perikaryon; IEA:Ensembl. DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl. DR GO; GO:0043195; C:terminal bouton; IEA:Ensembl. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0005169; F:neurotrophin TRKB receptor binding; IBA:GO_Central. DR GO; GO:0048675; P:axon extension; IDA:MGI. DR GO; GO:0007411; P:axon guidance; IMP:MGI. DR GO; GO:0007412; P:axon target recognition; IMP:MGI. DR GO; GO:0001662; P:behavioral fear response; IMP:MGI. DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl. DR GO; GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl. DR GO; GO:0002544; P:chronic inflammatory response; IEA:Ensembl. DR GO; GO:0016358; P:dendrite development; IMP:MGI. DR GO; GO:0097484; P:dendrite extension; IDA:MGI. DR GO; GO:0042596; P:fear response; IMP:MGI. DR GO; GO:0007631; P:feeding behavior; IMP:MGI. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IDA:MGI. DR GO; GO:0014047; P:glutamate secretion; IPI:MGI. DR GO; GO:0048839; P:inner ear development; IMP:MGI. DR GO; GO:0007612; P:learning; IEA:Ensembl. DR GO; GO:0007611; P:learning or memory; IMP:MGI. DR GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI. DR GO; GO:0060548; P:negative regulation of cell death; IMP:MGI. DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IDA:MGI. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI. DR GO; GO:0045843; P:negative regulation of striated muscle tissue development; IEA:Ensembl. DR GO; GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IDA:MGI. DR GO; GO:0021675; P:nerve development; IMP:MGI. DR GO; GO:0008038; P:neuron recognition; IMP:MGI. DR GO; GO:2000324; P:positive regulation of glucocorticoid receptor signaling pathway; ISO:MGI. DR GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:Ensembl. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:MGI. DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:MGI. DR GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl. DR GO; GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Ensembl. DR GO; GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IMP:MGI. DR GO; GO:0019222; P:regulation of metabolic process; IMP:MGI. DR GO; GO:0043523; P:regulation of neuron apoptotic process; IDA:MGI. DR GO; GO:0046668; P:regulation of retinal cell programmed cell death; IDA:MGI. DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl. DR GO; GO:0048167; P:regulation of synaptic plasticity; IDA:MGI. DR GO; GO:0014823; P:response to activity; IEA:Ensembl. DR GO; GO:0072347; P:response to anesthetic; IEA:Ensembl. DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl. DR GO; GO:0014076; P:response to fluoxetine; IEA:Ensembl. DR GO; GO:0032094; P:response to food; IEA:Ensembl. DR GO; GO:0009725; P:response to hormone; IEA:Ensembl. DR GO; GO:0055093; P:response to hyperoxia; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR GO; GO:1902065; P:response to L-glutamate; IEA:Ensembl. DR GO; GO:0009642; P:response to light intensity; IEA:Ensembl. DR GO; GO:0035864; P:response to potassium ion; IEA:Ensembl. DR GO; GO:0033189; P:response to vitamin A; IEA:Ensembl. DR GO; GO:0061193; P:taste bud development; IMP:MGI. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR GO; GO:0001657; P:ureteric bud development; IDA:MGI. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589; PTHR11589; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00001505}; KW Growth factor {ECO:0000256|SAAS:SAAS00159974}. SQ SEQUENCE 249 AA; 28123 MW; 90CE1F16BB235C97 CRC64; MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR //