ID Q541P3_MOUSE Unreviewed; 249 AA. AC Q541P3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 02-OCT-2024, entry version 156. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; GN Name=Bdnf {ECO:0000313|EMBL:AAL27785.1, ECO:0000313|MGI:MGI:88145}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL27785.1}; RN [1] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RX PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004; RA Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.; RT "Rodent BDNF genes, novel promoters, novel splice variants, and regulation RT by cocaine."; RL Brain Res. 1067:1-12(2006). RN [3] {ECO:0000313|EMBL:ABM30155.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 x CBA {ECO:0000313|EMBL:ABM30155.1}; RX PubMed=17149751; DOI=10.1002/jnr.21139; RA Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.; RT "Mouse and rat BDNF gene structure and expression revisited."; RL J. Neurosci. Res. 85:525-535(2007). CC -!- FUNCTION: During development, promotes the survival and differentiation CC of selected neuronal populations of the peripheral and central nervous CC systems. Participates in axonal growth, pathfinding and in the CC modulation of dendritic growth and morphology. Major regulator of CC synaptic transmission and plasticity at adult synapses in many regions CC of the CNS. {ECO:0000256|RuleBase:RU364086}. CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. CC {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY057907; AAL27784.1; -; Genomic_DNA. DR EMBL; AY057908; AAL27785.1; -; mRNA. DR EMBL; AY057909; AAL27786.1; -; mRNA. DR EMBL; AY057910; AAL27787.1; -; mRNA. DR EMBL; AY057911; AAL27788.1; -; mRNA. DR EMBL; AY057912; AAL27789.1; -; mRNA. DR EMBL; AY057913; AAL27790.1; -; mRNA. DR EMBL; AY057914; AAL27791.1; -; mRNA. DR EMBL; AY231131; AAO74602.1; -; mRNA. DR EMBL; AY231132; AAO74603.1; -; mRNA. DR EMBL; EF125669; ABM30155.1; -; mRNA. DR EMBL; EF125670; ABM30156.1; -; mRNA. DR EMBL; EF125671; ABM30157.1; -; mRNA. DR EMBL; EF125672; ABM30158.1; -; mRNA. DR EMBL; EF125673; ABM30159.1; -; mRNA. DR EMBL; EF125674; ABM30160.1; -; mRNA. DR EMBL; EF125681; ABM30167.1; -; mRNA. DR EMBL; EF125682; ABM30168.1; -; mRNA. DR EMBL; EF125683; ABM30169.1; -; mRNA. DR EMBL; EF125684; ABM30170.1; -; mRNA. DR EMBL; EF125685; ABM30171.1; -; mRNA. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_031566.4; NM_007540.4. DR AlphaFoldDB; Q541P3; -. DR SMR; Q541P3; -. DR Antibodypedia; 4032; 1365 antibodies from 50 providers. DR DNASU; 12064; -. DR GeneID; 12064; -. DR KEGG; mmu:12064; -. DR AGR; MGI:88145; -. DR CTD; 627; -. DR MGI; MGI:88145; Bdnf. DR VEuPathDB; HostDB:ENSMUSG00000048482; -. DR HOGENOM; CLU_059942_0_0_1; -. DR OrthoDB; 5399313at2759; -. DR BioGRID-ORCS; 12064; 3 hits in 81 CRISPR screens. DR ExpressionAtlas; Q541P3; baseline and differential. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001789-1}; KW Growth factor {ECO:0000256|RuleBase:RU364086}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|RuleBase:RU364086}. FT SIGNAL 1..18 FT /evidence="ECO:0000256|RuleBase:RU364086" FT CHAIN 19..249 FT /note="Brain-derived neurotrophic factor" FT /evidence="ECO:0000256|RuleBase:RU364086" FT /id="PRO_5014205862" FT DOMAIN 135..242 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT DISULFID 143..210 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 188..239 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 198..241 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" SQ SEQUENCE 249 AA; 28123 MW; 90CE1F16BB235C97 CRC64; MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR //