ID Q541P3_MOUSE Unreviewed; 249 AA. AC Q541P3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 10-MAY-2017, entry version 114. DE SubName: Full=Brain-derived neurotrophic factor {ECO:0000313|EMBL:AAL27784.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF1 {ECO:0000313|EMBL:AAL27785.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF2C {ECO:0000313|EMBL:AAL27788.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF3 {ECO:0000313|EMBL:AAL27789.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF4 {ECO:0000313|EMBL:AAL27790.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIA {ECO:0000313|EMBL:ABM30156.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIB {ECO:0000313|EMBL:ABM30157.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant III {ECO:0000313|EMBL:ABM30167.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant V {ECO:0000313|EMBL:ABM30168.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant VIII {ECO:0000313|EMBL:ABM30170.1}; GN Name=Bdnf {ECO:0000313|EMBL:AAL27785.1, ECO:0000313|MGI:MGI:88145}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAO74602.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO74602.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RX PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004; RA Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.; RT "Rodent BDNF genes, novel promoters, novel splice variants, and RT regulation by cocaine."; RL Brain Res. 1067:1-12(2006). RN [4] {ECO:0000313|EMBL:ABM30155.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 x CBA {ECO:0000313|EMBL:ABM30155.1}; RX PubMed=17149751; DOI=10.1002/jnr.21139; RA Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.; RT "Mouse and rat BDNF gene structure and expression revisited."; RL J. Neurosci. Res. 85:525-535(2007). CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|SAAS:SAAS00543519}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY057907; AAL27784.1; -; Genomic_DNA. DR EMBL; AY057908; AAL27785.1; -; mRNA. DR EMBL; AY057909; AAL27786.1; -; mRNA. DR EMBL; AY057910; AAL27787.1; -; mRNA. DR EMBL; AY057911; AAL27788.1; -; mRNA. DR EMBL; AY057912; AAL27789.1; -; mRNA. DR EMBL; AY057913; AAL27790.1; -; mRNA. DR EMBL; AY057914; AAL27791.1; -; mRNA. DR EMBL; AY231131; AAO74602.1; -; mRNA. DR EMBL; AY231132; AAO74603.1; -; mRNA. DR EMBL; EF125669; ABM30155.1; -; mRNA. DR EMBL; EF125670; ABM30156.1; -; mRNA. DR EMBL; EF125671; ABM30157.1; -; mRNA. DR EMBL; EF125672; ABM30158.1; -; mRNA. DR EMBL; EF125673; ABM30159.1; -; mRNA. DR EMBL; EF125674; ABM30160.1; -; mRNA. DR EMBL; EF125681; ABM30167.1; -; mRNA. DR EMBL; EF125682; ABM30168.1; -; mRNA. DR EMBL; EF125683; ABM30169.1; -; mRNA. DR EMBL; EF125684; ABM30170.1; -; mRNA. DR EMBL; EF125685; ABM30171.1; -; mRNA. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_031566.4; NM_007540.4. DR RefSeq; NP_031566.4; NM_007540.4. DR RefSeq; NP_031566.4; NM_007540.4. DR UniGene; Mm.1442; -. DR STRING; 10090.ENSMUSP00000057989; -. DR GeneID; 12064; -. DR KEGG; mmu:12064; -. DR CTD; 627; -. DR MGI; MGI:88145; Bdnf. DR eggNOG; ENOG410IH7X; Eukaryota. DR eggNOG; ENOG410XRPH; LUCA. DR HOVERGEN; HBG006494; -. DR KO; K04355; -. DR Bgee; ENSMUSG00000048482; -. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF15; PTHR11589:SF15; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1, KW ECO:0000256|SAAS:SAAS00022131}; KW Growth factor {ECO:0000256|SAAS:SAAS00426801}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010139260. FT DOMAIN 135 242 NGF. {ECO:0000259|SMART:SM00140}. FT DISULFID 143 210 {ECO:0000256|PIRSR:PIRSR001789-1}. FT DISULFID 188 239 {ECO:0000256|PIRSR:PIRSR001789-1}. FT DISULFID 198 241 {ECO:0000256|PIRSR:PIRSR001789-1}. SQ SEQUENCE 249 AA; 28123 MW; 90CE1F16BB235C97 CRC64; MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR //