ID Q541P3_MOUSE Unreviewed; 249 AA. AC Q541P3; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 11-MAY-2016, entry version 103. DE SubName: Full=Brain-derived neurotrophic factor {ECO:0000313|EMBL:AAL27784.1, ECO:0000313|Ensembl:ENSMUSP00000106672}; DE SubName: Full=Brain-derived neurotrophic factor BDNF1 {ECO:0000313|EMBL:AAL27785.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF2B {ECO:0000313|EMBL:AAL27787.1}; DE SubName: Full=Brain-derived neurotrophic factor BDNF2C {ECO:0000313|EMBL:AAL27788.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant I {ECO:0000313|EMBL:ABM30155.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIB {ECO:0000313|EMBL:ABM30157.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IIC {ECO:0000313|EMBL:ABM30158.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant III {ECO:0000313|EMBL:ABM30167.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IV {ECO:0000313|EMBL:ABM30159.1}; DE SubName: Full=Brain-derived neurotrophic factor transcript variant IXA {ECO:0000313|EMBL:ABM30171.1}; GN Name=Bdnf {ECO:0000313|EMBL:AAL27785.1, GN ECO:0000313|Ensembl:ENSMUSP00000106672, ECO:0000313|MGI:MGI:88145}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAO74602.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAO74602.1}; RA Liu Q.-R., Walther D., Uhl G.R.; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAL27785.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAL27785.1}; RX PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004; RA Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.; RT "Rodent BDNF genes, novel promoters, novel splice variants, and RT regulation by cocaine."; RL Brain Res. 1067:1-12(2006). RN [4] {ECO:0000313|EMBL:ABM30155.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 x CBA {ECO:0000313|EMBL:ABM30155.1}; RX PubMed=17149751; DOI=10.1002/jnr.21139; RA Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.; RT "Mouse and rat BDNF gene structure and expression revisited."; RL J. Neurosci. Res. 85:525-535(2007). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000106672, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106672, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000106672} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106672}; RG Ensembl; RL Submitted (AUG-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|SAAS:SAAS00536750}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL732477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY057907; AAL27784.1; -; Genomic_DNA. DR EMBL; AY057908; AAL27785.1; -; mRNA. DR EMBL; AY057909; AAL27786.1; -; mRNA. DR EMBL; AY057910; AAL27787.1; -; mRNA. DR EMBL; AY057911; AAL27788.1; -; mRNA. DR EMBL; AY057912; AAL27789.1; -; mRNA. DR EMBL; AY057913; AAL27790.1; -; mRNA. DR EMBL; AY057914; AAL27791.1; -; mRNA. DR EMBL; AY231131; AAO74602.1; -; mRNA. DR EMBL; AY231132; AAO74603.1; -; mRNA. DR EMBL; EF125669; ABM30155.1; -; mRNA. DR EMBL; EF125670; ABM30156.1; -; mRNA. DR EMBL; EF125671; ABM30157.1; -; mRNA. DR EMBL; EF125672; ABM30158.1; -; mRNA. DR EMBL; EF125673; ABM30159.1; -; mRNA. DR EMBL; EF125674; ABM30160.1; -; mRNA. DR EMBL; EF125681; ABM30167.1; -; mRNA. DR EMBL; EF125682; ABM30168.1; -; mRNA. DR EMBL; EF125683; ABM30169.1; -; mRNA. DR EMBL; EF125684; ABM30170.1; -; mRNA. DR EMBL; EF125685; ABM30171.1; -; mRNA. DR RefSeq; NP_001041604.1; NM_001048139.1. DR RefSeq; NP_001041606.1; NM_001048141.1. DR RefSeq; NP_001041607.1; NM_001048142.1. DR RefSeq; NP_001272345.1; NM_001285416.1. DR RefSeq; NP_001272346.1; NM_001285417.1. DR RefSeq; NP_001272347.1; NM_001285418.1. DR RefSeq; NP_001272348.1; NM_001285419.1. DR RefSeq; NP_001272349.1; NM_001285420.1. DR RefSeq; NP_001272350.1; NM_001285421.1. DR RefSeq; NP_001272351.1; NM_001285422.1. DR RefSeq; NP_001303239.1; NM_001316310.1. DR RefSeq; NP_031566.4; NM_007540.4. DR UniGene; Mm.1442; -. DR STRING; 10090.ENSMUSP00000057989; -. DR Ensembl; ENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482. DR Ensembl; ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482. DR Ensembl; ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482. DR GeneID; 12064; -. DR KEGG; mmu:12064; -. DR CTD; 627; -. DR MGI; MGI:88145; Bdnf. DR eggNOG; ENOG410IH7X; Eukaryota. DR eggNOG; ENOG410XRPH; LUCA. DR GeneTree; ENSGT00390000007725; -. DR HOVERGEN; HBG006494; -. DR KO; K04355; -. DR NextBio; 280377; -. DR Proteomes; UP000000589; Chromosome 2. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00416291}; KW Growth factor {ECO:0000256|SAAS:SAAS00416339}; KW Proteomics identification {ECO:0000213|MaxQB:Q541P3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 249 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007209658. FT DOMAIN 135 242 NGF. {ECO:0000259|SMART:SM00140}. SQ SEQUENCE 249 AA; 28123 MW; 90CE1F16BB235C97 CRC64; MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR //