ID   Q53XY6_HUMAN            Unreviewed;       170 AA.
AC   Q53XY6;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   02-OCT-2024, entry version 148.
DE   SubName: Full=Placental growth factor {ECO:0000313|EMBL:AAP35846.1, ECO:0000313|EMBL:AGC09600.1};
DE   SubName: Full=Placental growth factor, vascular endothelial growth factor-related protein, isoform CRA_a {ECO:0000313|EMBL:EAW81207.1};
GN   Name=PGF {ECO:0000313|EMBL:ABY87550.1};
GN   ORFNames=hCG_22349 {ECO:0000313|EMBL:EAW81207.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAP35846.1};
RN   [1] {ECO:0000313|EMBL:EAW81207.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
RA   Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
RA   Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
RA   Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
RA   McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
RA   Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
RA   Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
RA   Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
RA   Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
RA   Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
RA   Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
RA   Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
RA   Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
RA   Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
RA   Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
RA   Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
RA   Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
RA   Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
RA   Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
RA   Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
RA   Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
RA   Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
RA   McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
RA   Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
RA   Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
RA   Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
RA   Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
RA   Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
RA   Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
RA   Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
RA   Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
RA   Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
RA   Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
RA   Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
RA   Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
RA   Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
RA   Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:AAP35846.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAW81207.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ABY87550.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rieder M.J., da Ponte S.H., Bertucci C.F., Nickerson D.A.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AGC09600.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rieder M.J., Bertucci C., Stanaway I.B., Johnson E.J., Swanson J.E.,
RA   Siegel D.L., da Ponte S.H., Igartua C., Patterson K., Nickerson D.A.;
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR   EMBL; BT007182; AAP35846.1; -; mRNA.
DR   EMBL; EU332861; ABY87550.1; -; Genomic_DNA.
DR   EMBL; JX512453; AGC09600.1; -; Genomic_DNA.
DR   EMBL; CH471061; EAW81207.1; -; Genomic_DNA.
DR   RefSeq; NP_002623.2; NM_002632.5.
DR   AlphaFoldDB; Q53XY6; -.
DR   SMR; Q53XY6; -.
DR   Antibodypedia; 12927; 1020 antibodies from 45 providers.
DR   DNASU; 5228; -.
DR   GeneID; 5228; -.
DR   KEGG; hsa:5228; -.
DR   UCSC; uc001xqz.4; human.
DR   CTD; 5228; -.
DR   DisGeNET; 5228; -.
DR   PharmGKB; PA33231; -.
DR   VEuPathDB; HostDB:ENSG00000119630; -.
DR   OMA; KPTDCHL; -.
DR   OrthoDB; 4231319at2759; -.
DR   BioGRID-ORCS; 5228; 8 hits in 1155 CRISPR screens.
DR   ChiTaRS; PGF; human.
DR   ExpressionAtlas; Q53XY6; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0042056; F:chemoattractant activity; IEA:TreeGrafter.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:TreeGrafter.
DR   GO; GO:0050930; P:induction of positive chemotaxis; IEA:TreeGrafter.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:TreeGrafter.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter.
DR   GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:TreeGrafter.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:TreeGrafter.
DR   GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:TreeGrafter.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   InterPro; IPR050507; PDGF/VEGF_growth_factor.
DR   PANTHER; PTHR12025:SF9; PLACENTA GROWTH FACTOR; 1.
DR   PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   2: Evidence at transcript level;
KW   Growth factor {ECO:0000256|RuleBase:RU003818};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..170
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014309522"
FT   DOMAIN          39..135
FT                   /note="Platelet-derived growth factor (PDGF) family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50278"
FT   REGION          137..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   170 AA;  19338 MW;  02CDE4CC54A09637 CRC64;
     MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD
     VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL
     TFSQHVRCEC RPLREKMKPE RRRPKGRGKR RREKQRPTDC HLCGDAVPRR
//