ID Q53XY6_HUMAN Unreviewed; 170 AA. AC Q53XY6; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 29-MAY-2024, entry version 146. DE SubName: Full=Placental growth factor {ECO:0000313|EMBL:AAP35846.1, ECO:0000313|EMBL:AGC09600.1}; DE SubName: Full=Placental growth factor, vascular endothelial growth factor-related protein, isoform CRA_a {ECO:0000313|EMBL:EAW81207.1}; GN Name=PGF {ECO:0000313|EMBL:ABY87550.1}; GN ORFNames=hCG_22349 {ECO:0000313|EMBL:EAW81207.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAP35846.1}; RN [1] {ECO:0000313|EMBL:EAW81207.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:AAP35846.1} RP NUCLEOTIDE SEQUENCE. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:EAW81207.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ABY87550.1} RP NUCLEOTIDE SEQUENCE. RA Rieder M.J., da Ponte S.H., Bertucci C.F., Nickerson D.A.; RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AGC09600.1} RP NUCLEOTIDE SEQUENCE. RA Rieder M.J., Bertucci C., Stanaway I.B., Johnson E.J., Swanson J.E., RA Siegel D.L., da Ponte S.H., Igartua C., Patterson K., Nickerson D.A.; RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT007182; AAP35846.1; -; mRNA. DR EMBL; EU332861; ABY87550.1; -; Genomic_DNA. DR EMBL; JX512453; AGC09600.1; -; Genomic_DNA. DR EMBL; CH471061; EAW81207.1; -; Genomic_DNA. DR RefSeq; NP_002623.2; NM_002632.5. DR AlphaFoldDB; Q53XY6; -. DR SMR; Q53XY6; -. DR Antibodypedia; 12927; 1065 antibodies from 44 providers. DR DNASU; 5228; -. DR GeneID; 5228; -. DR KEGG; hsa:5228; -. DR UCSC; uc001xqz.4; human. DR CTD; 5228; -. DR DisGeNET; 5228; -. DR PharmGKB; PA33231; -. DR VEuPathDB; HostDB:ENSG00000119630; -. DR OMA; KPTDCHL; -. DR OrthoDB; 4231319at2759; -. DR BioGRID-ORCS; 5228; 8 hits in 1155 CRISPR screens. DR ChiTaRS; PGF; human. DR GenomeRNAi; 5228; -. DR ExpressionAtlas; Q53XY6; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0042056; F:chemoattractant activity; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:TreeGrafter. DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:TreeGrafter. DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter. DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:TreeGrafter. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:TreeGrafter. DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter. DR GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter. DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:TreeGrafter. DR CDD; cd00135; PDGF; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR023581; PD_growth_factor_CS. DR InterPro; IPR000072; PDGF/VEGF_dom. DR PANTHER; PTHR12025:SF9; PLACENTA GROWTH FACTOR; 1. DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1. DR Pfam; PF00341; PDGF; 1. DR SMART; SM00141; PDGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00249; PDGF_1; 1. DR PROSITE; PS50278; PDGF_2; 1. PE 2: Evidence at transcript level; KW Growth factor {ECO:0000256|RuleBase:RU003818}; KW Mitogen {ECO:0000256|ARBA:ARBA00023246}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..170 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014309522" FT DOMAIN 39..135 FT /note="Platelet-derived growth factor (PDGF) family FT profile" FT /evidence="ECO:0000259|PROSITE:PS50278" FT REGION 137..170 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 153..170 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 170 AA; 19338 MW; 02CDE4CC54A09637 CRC64; MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL TFSQHVRCEC RPLREKMKPE RRRPKGRGKR RREKQRPTDC HLCGDAVPRR //