ID Q53XM0_HUMAN Unreviewed; 736 AA. AC Q53XM0; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 06-FEB-2007, entry version 17. DE Dishevelled, dsh homolog 2 (Drosophila) (Dishevelled, dsh homolog 2 DE (Drosophila), isoform CRA_a). GN Name=DVL2; ORFNames=hCG_42002; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May play a role in the signal transduction pathway CC mediated by multiple Wnt genes (By similarity). CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT009822; AAP88824.1; -; mRNA. DR EMBL; CH471108; EAW90244.1; -; Genomic_DNA. DR UniGene; Hs.118640; -. DR SMR; Q53XM0; 265-353. DR Ensembl; ENSG00000004975; Homo sapiens. DR HGNC; HGNC:3086; DVL2. DR ArrayExpress; Q53XM0; -. DR RZPD-ProtExp; IOH9688; -. DR RZPD-ProtExp; M0056; -. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0005515; F:protein binding; IEA:InterPro. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0007222; P:frizzled signaling pathway; IEA:InterPro. DR GO; GO:0007242; P:intracellular signaling cascade; IEA:InterPro. DR GO; GO:0007275; P:multicellular organismal development; IEA:InterPro. DR InterPro; IPR000591; DEP. DR InterPro; IPR008339; Dishevell. DR InterPro; IPR003351; Dishevelled. DR InterPro; IPR008341; Dishevelled_2. DR InterPro; IPR001158; DIX. DR InterPro; IPR001478; PDZ. DR InterPro; IPR011991; Wing_hlx_DNA_bd. DR Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1. DR Pfam; PF00610; DEP; 1. DR Pfam; PF02377; Dishevelled; 1. DR Pfam; PF00778; DIX; 1. DR Pfam; PF00595; PDZ; 1. DR PRINTS; PR01760; DISHEVELLED. DR PRINTS; PR01762; DISHEVELLED2. DR ProDom; PD003639; DIX; 1. DR SMART; SM00021; DAX; 1. DR SMART; SM00049; DEP; 1. DR SMART; SM00228; PDZ; 1. DR PROSITE; PS50186; DEP; 1. DR PROSITE; PS50841; DIX; 1. DR PROSITE; PS50106; PDZ; 1. KW Wnt signaling pathway. SQ SEQUENCE 736 AA; 78948 MW; 4BAD95B6C3FE531B CRC64; MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM //