ID Q53XL7_HUMAN Unreviewed; 173 AA. AC Q53XL7; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 08-APR-2008, entry version 18. DE Glycine cleavage system protein H (Aminomethyl carrier) (Glycine DE cleavage system protein H (Aminomethyl carrier), isoform CRA_a). GN Name=GCSH; ORFNames=hCG_1980047; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The glycine cleavage system catalyzes the degradation of CC glycine. The H protein shuttles the methylamine group of glycine CC from the P protein to the T protein (By similarity). CC -!- COFACTOR: Binds 1 lipoyl cofactor covalently (By similarity). CC -!- SUBUNIT: The glycine cleavage system is composed of four proteins: CC P, T, L and H (By similarity). CC -!- SIMILARITY: Contains 1 lipoyl-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT009827; AAP88829.1; -; mRNA. DR EMBL; CH471114; EAW95545.1; -; Genomic_DNA. DR UniGene; Hs.546256; -. DR Ensembl; ENSG00000140905; Homo sapiens. DR HGNC; HGNC:4208; GCSH. DR GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro. DR GO; GO:0031405; F:lipoic acid binding; IEA:UniProtKB-KW. DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro. DR InterPro; IPR003016; 2-oxoA_DHase_lipoyl-BS. DR InterPro; IPR002930; GCV_H. DR PANTHER; PTHR11715; GCV_H; 1. DR Pfam; PF01597; GCV_H; 1. DR PROSITE; PS00189; LIPOYL; 1. PE 2: Evidence at transcript level; KW Lipoyl. SQ SEQUENCE 173 AA; 18911 MW; BA1C1AFCB6C13ACC CRC64; MALRVVRSVR ALLCTLRAVP LPAAPCPPRP WQLGVGAVRT LRTGPALLSV RKFTEKHEWV TTENGIGTVG ISNFAQEALG DVVYCSLPEV GTKLNKQDEF GALESVKAAS ELYSPLSGEV TEINEALAEN PGLVNKSCYE DGWLIKMTLS NPSELDELMS EEAYEKYIKS IEE //