ID Q53S60_HUMAN Unreviewed; 451 AA. AC Q53S60; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 25-OCT-2017, entry version 84. DE SubName: Full=Bile salt export pump {ECO:0000313|Ensembl:ENSP00000480206}; DE SubName: Full=Uncharacterized protein ABCB11 {ECO:0000313|EMBL:AAY24100.1}; DE Flags: Fragment; GN Name=ABCB11 {ECO:0000313|EMBL:AAY24100.1, GN ECO:0000313|Ensembl:ENSP00000480206}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAY24100.1}; RN [1] {ECO:0000313|EMBL:AAY24100.1} RP NUCLEOTIDE SEQUENCE. RA Courtney L., VanBrunt A., Kozlowicz A.; RT "The sequence of Homo sapiens BAC clone RP11-750D14."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAY24100.1} RP NUCLEOTIDE SEQUENCE. RA Waterston R.H.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAY24100.1} RP NUCLEOTIDE SEQUENCE. RA Waterston R.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000480206, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [5] {ECO:0000313|EMBL:AAY24100.1} RP NUCLEOTIDE SEQUENCE. RA Wilson R.K.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [7] {ECO:0000313|Ensembl:ENSP00000480206} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC069137; AAY24100.1; -; Genomic_DNA. DR UniGene; Hs.658439; -. DR Ensembl; ENST00000618180; ENSP00000480206; ENSG00000276582. DR UCSC; uc032qzp.2; human. DR HGNC; HGNC:42; ABCB11. DR eggNOG; KOG0055; Eukaryota. DR eggNOG; COG1132; LUCA. DR HOVERGEN; HBG008358; -. DR OrthoDB; EOG091G0HVA; -. DR ChiTaRS; ABCB11; human. DR Proteomes; UP000005640; Chromosome 2. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. DR GO; GO:0015721; P:bile acid and bile salt transport; IEA:InterPro. DR Gene3D; 1.20.1560.10; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR036640; ABC1_TM_sf. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR030278; BSEP. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR24221:SF165; PTHR24221:SF165; 1. DR Pfam; PF00664; ABC_membrane; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF90123; SSF90123; 1. DR PROSITE; PS50929; ABC_TM1F; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434}; KW Proteomics identification {ECO:0000213|MaxQB:Q53S60, KW ECO:0000213|PeptideAtlas:Q53S60}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 18 43 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 146 165 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 173 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT DOMAIN 208 446 ABC transporter. {ECO:0000259|PROSITE: FT PS50893}. FT NP_BIND 243 250 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00434}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAY24100.1, FT ECO:0000313|Ensembl:ENSP00000480206}. SQ SEQUENCE 451 AA; 49465 MW; ECB159B211346084 CRC64; AAGSQIGMIV NSFTNVTVAM IIAFSFSWKL SLVILCFFPF LALSGATQTR MLTGFASRDK QALEMVGQIT NEALSNIRTV AGIGKERRFI EALETELEKP FKTAIQKANI YGFCFAFAQC IMFIANSASY RYGGYLISNE GLHFSYVFRV ISAVVLSATA LGRAFSYTPS YAKAKISAAR FFQLLDRQPP ISVYNTAGEK WDNFQGKIDF VDCKFTYPSR PDSQVLNGLS VSISPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGKVMID GHDSKKVNVQ FLRSNIGIVS QEPVLFACSI MDNIKYGDNT KEIPMERVIA AAKQAQLHDF VMSLPEKYET NVGSQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQVA LDKAREGRTC IVIAHRLSTI QNADIIAVMA QGVVIEKGTH EELMAQKGAY YKLVTTGSPI S //