ID KR132_HUMAN Reviewed; 175 AA. AC Q52LG2; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2005, sequence version 1. DT 08-NOV-2023, entry version 113. DE RecName: Full=Keratin-associated protein 13-2; GN Name=KRTAP13-2; Synonyms=KAP13.2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Hair root; RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.; RT "Identification of complete keratin-associated protein (KAP) gene cluster RT spanning 800 kb region on human chromosome 21q22.11."; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated proteins (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}. CC -!- INTERACTION: CC Q52LG2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11953846, EBI-12224467; CC Q52LG2; P50995: ANXA11; NbExp=3; IntAct=EBI-11953846, EBI-715243; CC Q52LG2; P41182: BCL6; NbExp=3; IntAct=EBI-11953846, EBI-765407; CC Q52LG2; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-11953846, EBI-7317823; CC Q52LG2; O43439-4: CBFA2T2; NbExp=3; IntAct=EBI-11953846, EBI-11954144; CC Q52LG2; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11953846, EBI-11977221; CC Q52LG2; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-11953846, EBI-1104933; CC Q52LG2; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11953846, EBI-10961624; CC Q52LG2; O75909-2: CCNK; NbExp=3; IntAct=EBI-11953846, EBI-12010594; CC Q52LG2; Q9H5F2: CFAP68; NbExp=3; IntAct=EBI-11953846, EBI-718615; CC Q52LG2; P05813: CRYBA1; NbExp=3; IntAct=EBI-11953846, EBI-7043337; CC Q52LG2; A8MUP2: CSKMT; NbExp=3; IntAct=EBI-11953846, EBI-12842046; CC Q52LG2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11953846, EBI-3867333; CC Q52LG2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11953846, EBI-744099; CC Q52LG2; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-11953846, EBI-946972; CC Q52LG2; Q16134: ETFDH; NbExp=3; IntAct=EBI-11953846, EBI-2870454; CC Q52LG2; Q9NW38: FANCL; NbExp=3; IntAct=EBI-11953846, EBI-2339898; CC Q52LG2; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-11953846, EBI-2510157; CC Q52LG2; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11953846, EBI-11977403; CC Q52LG2; P23771-2: GATA3; NbExp=3; IntAct=EBI-11953846, EBI-6672518; CC Q52LG2; P57678: GEMIN4; NbExp=3; IntAct=EBI-11953846, EBI-356700; CC Q52LG2; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11953846, EBI-11975289; CC Q52LG2; Q13227: GPS2; NbExp=3; IntAct=EBI-11953846, EBI-713355; CC Q52LG2; P28799: GRN; NbExp=3; IntAct=EBI-11953846, EBI-747754; CC Q52LG2; P31943: HNRNPH1; NbExp=3; IntAct=EBI-11953846, EBI-351590; CC Q52LG2; P49639: HOXA1; NbExp=5; IntAct=EBI-11953846, EBI-740785; CC Q52LG2; O43593: HR; NbExp=3; IntAct=EBI-11953846, EBI-2880706; CC Q52LG2; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11953846, EBI-4397613; CC Q52LG2; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11953846, EBI-6426443; CC Q52LG2; Q5T749: KPRP; NbExp=3; IntAct=EBI-11953846, EBI-10981970; CC Q52LG2; P12035: KRT3; NbExp=3; IntAct=EBI-11953846, EBI-2430095; CC Q52LG2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11953846, EBI-11959885; CC Q52LG2; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11953846, EBI-10172150; CC Q52LG2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11953846, EBI-1052037; CC Q52LG2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11953846, EBI-10176379; CC Q52LG2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11953846, EBI-11953334; CC Q52LG2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-11953846, EBI-11992140; CC Q52LG2; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11953846, EBI-3957672; CC Q52LG2; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11953846, EBI-9996449; CC Q52LG2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11953846, EBI-3957694; CC Q52LG2; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11953846, EBI-11958132; CC Q52LG2; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11953846, EBI-11993254; CC Q52LG2; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11953846, EBI-1044640; CC Q52LG2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11953846, EBI-746778; CC Q52LG2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11953846, EBI-16439278; CC Q52LG2; Q86SG6: NEK8; NbExp=3; IntAct=EBI-11953846, EBI-1752987; CC Q52LG2; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-11953846, EBI-12868744; CC Q52LG2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11953846, EBI-22310682; CC Q52LG2; O43482: OIP5; NbExp=3; IntAct=EBI-11953846, EBI-536879; CC Q52LG2; P32242: OTX1; NbExp=3; IntAct=EBI-11953846, EBI-740446; CC Q52LG2; P07237: P4HB; NbExp=3; IntAct=EBI-11953846, EBI-395883; CC Q52LG2; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-11953846, EBI-11022007; CC Q52LG2; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-11953846, EBI-14131832; CC Q52LG2; P78337: PITX1; NbExp=3; IntAct=EBI-11953846, EBI-748265; CC Q52LG2; Q16633: POU2AF1; NbExp=3; IntAct=EBI-11953846, EBI-943588; CC Q52LG2; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-11953846, EBI-12000762; CC Q52LG2; Q6P9E2: RECK; NbExp=3; IntAct=EBI-11953846, EBI-10253121; CC Q52LG2; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-11953846, EBI-372094; CC Q52LG2; Q9H1K4: SLC25A18; NbExp=3; IntAct=EBI-11953846, EBI-6269587; CC Q52LG2; O75093: SLIT1; NbExp=3; IntAct=EBI-11953846, EBI-947791; CC Q52LG2; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-11953846, EBI-12275818; CC Q52LG2; P09234: SNRPC; NbExp=3; IntAct=EBI-11953846, EBI-766589; CC Q52LG2; Q9Y4P9-2: SPEF1; NbExp=3; IntAct=EBI-11953846, EBI-12303571; CC Q52LG2; O75716: STK16; NbExp=3; IntAct=EBI-11953846, EBI-749295; CC Q52LG2; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-11953846, EBI-11974855; CC Q52LG2; Q96LM6: TEX37; NbExp=3; IntAct=EBI-11953846, EBI-743976; CC Q52LG2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11953846, EBI-11741437; CC Q52LG2; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11953846, EBI-949753; CC Q52LG2; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-11953846, EBI-8451480; CC Q52LG2; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-11953846, EBI-2130449; CC Q52LG2; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-11953846, EBI-12023322; CC Q52LG2; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-11953846, EBI-3918381; CC Q52LG2; Q8IV45: UNC5CL; NbExp=3; IntAct=EBI-11953846, EBI-12238241; CC Q52LG2; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11953846, EBI-11957216; CC Q52LG2; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11953846, EBI-11957238; CC Q52LG2; Q15915: ZIC1; NbExp=3; IntAct=EBI-11953846, EBI-11963196; CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB096938; BAE46353.1; -; mRNA. DR EMBL; BC093934; AAH93934.1; -; mRNA. DR EMBL; BC093936; AAH93936.1; -; mRNA. DR CCDS; CCDS13589.1; -. DR RefSeq; NP_853652.1; NM_181621.3. DR AlphaFoldDB; Q52LG2; -. DR BioGRID; 130644; 108. DR IntAct; Q52LG2; 76. DR STRING; 9606.ENSP00000382777; -. DR iPTMnet; Q52LG2; -. DR PhosphoSitePlus; Q52LG2; -. DR BioMuta; KRTAP13-2; -. DR DMDM; 74735807; -. DR MassIVE; Q52LG2; -. DR PaxDb; 9606-ENSP00000382777; -. DR PeptideAtlas; Q52LG2; -. DR PRIDE; Q52LG2; -. DR ProteomicsDB; 62423; -. DR Antibodypedia; 81633; 1 antibodies from 1 providers. DR DNASU; 337959; -. DR Ensembl; ENST00000399889.4; ENSP00000382777.2; ENSG00000182816.9. DR GeneID; 337959; -. DR KEGG; hsa:337959; -. DR MANE-Select; ENST00000399889.4; ENSP00000382777.2; NM_181621.4; NP_853652.1. DR UCSC; uc002ynz.5; human. DR AGR; HGNC:18923; -. DR CTD; 337959; -. DR GeneCards; KRTAP13-2; -. DR HGNC; HGNC:18923; KRTAP13-2. DR HPA; ENSG00000182816; Tissue enriched (skin). DR neXtProt; NX_Q52LG2; -. DR OpenTargets; ENSG00000182816; -. DR PharmGKB; PA134994193; -. DR VEuPathDB; HostDB:ENSG00000182816; -. DR eggNOG; ENOG502STG2; Eukaryota. DR GeneTree; ENSGT00940000162756; -. DR HOGENOM; CLU_111618_0_0_1; -. DR InParanoid; Q52LG2; -. DR OMA; QEICWEP; -. DR OrthoDB; 5264457at2759; -. DR PhylomeDB; Q52LG2; -. DR TreeFam; TF337331; -. DR PathwayCommons; Q52LG2; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; Q52LG2; -. DR BioGRID-ORCS; 337959; 11 hits in 1135 CRISPR screens. DR GenomeRNAi; 337959; -. DR Pharos; Q52LG2; Tdark. DR PRO; PR:Q52LG2; -. DR Proteomes; UP000005640; Chromosome 21. DR RNAct; Q52LG2; Protein. DR Bgee; ENSG00000182816; Expressed in rectum and 26 other tissues. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR InterPro; IPR007951; KRTAP_PMG. DR Pfam; PF05287; PMG; 1. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..175 FT /note="Keratin-associated protein 13-2" FT /id="PRO_0000185201" FT REPEAT 46..55 FT /note="1" FT REPEAT 56..65 FT /note="2" FT REPEAT 66..75 FT /note="3" FT REPEAT 76..85 FT /note="4" FT REPEAT 92..101 FT /note="5" FT REGION 46..101 FT /note="5 X 10 AA approximate repeats" FT VARIANT 26 FT /note="R -> C (in dbSNP:rs16986753)" FT /id="VAR_053470" FT VARIANT 74 FT /note="S -> R (in dbSNP:rs3804010)" FT /id="VAR_053471" SQ SEQUENCE 175 AA; 18727 MW; 3C8B3B255CF9A1CD CRC64; MSYNCCSGNF SSRSCGDYLR YPASSRGFSY PSNLVYSTDL CSPSTCQLGS SLYRGCQEIC WEPTSCQTSY VESSPCQTSC YRPRTSLLCS PCKTTYSGSL GFGSSSCRSL GYGSRSCYSV GCGSSGVRSL GYGSCGFPSL GYGSGFCRPT YLASRSCQSP CYRPAYGSTF CRSTC //