ID Q51714 PRELIMINARY; PRT; 616 AA. AC Q51714; DT 01-JAN-1998 (TrEMBLrel. 05, Created) DT 01-JAN-1998 (TrEMBLrel. 05, Last sequence update) DT 01-MAY-1999 (TrEMBLrel. 10, Last annotation update) DE PROLYL ENDOPEPTIDASE (EC 3.4.21.26) (POST-PROLINE CLEAVING ENZYME) DE (PE). GN MLR-2. OS Pyrococcus furiosus. OC Archaea; Euryarchaeota; Thermococcales; Thermococcaceae; Pyrococcus. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=DSM 3638; RX MEDLINE; 95129900. RA ROBINSON K.A., BARTLEY D.A., ROBB F.T., SCHREIER H.J.; RT "A gene from the hyperthermophile Pyrococcus furiosus whose deduced RT product is homologous to members of the prolyl oligopeptidase family RT of proteases."; RL Gene 152:103-106(1995). CC -!- FUNCTION: CLEAVES PEPTIDE BONDS ON THE C-TERMINAL SIDE OF PROLYL CC RESIDUES WITHIN PEPTIDES THAT ARE UP TO APPROXIMATELY 30 AMINO CC ACIDS LONG. CC HAS AN ABSOLUTE REQUIREMENT FOR AN X-PRO BOND IN THE TRANS CC CONFIGURATION IMMEDIATELY PRECEDING THE PRO-Y SCISSIBLE BOND. CC -!- CATALYTIC ACTIVITY: HYDROLYSIS OF PRO-|-XAA >> ALA-|-XAA IN CC OLIGOPEPTIDES. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE CC PROLYL OLIGOPEPTIDASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U08343; AAA73423.1; -. DR PFAM; PF00326; Peptidase_S9; 1. KW Hydrolase; Serine protease. FT ACT_SITE 477 477 CHARGE RELAY SYSTEM (BY SIMILARITY). FT ACT_SITE 592 592 CHARGE RELAY SYSTEM (BY SIMILARITY). SQ SEQUENCE 616 AA; 70867 MW; 86AC623A CRC32; MEDPYIWMEN LEDERVLKII EEENKRFREF IGELSDKLFP EVWEQFSQPT IGMARITKKG IIASYSEKDR VVIKWFNGDV IVDSKELERE VGDEVLLQGF TTDEEGEKLA YSFSIGGADE GITRIIDLKT GEVIEEIKPS IWNITFLKDG YYFTRFYRKE KTPDGVNPPA ARMFWKDREG ERMVFGEGLT SGYFMSIRKS SDGKFAIVTL TYGWNQGEVY IGPIDNPQEW KKVYSASVPV EAIDVVNGKL YILTKEGKGL GKIIAIKNGK IDEVIPEGEF PLEWAVIVRD KILAGRLVHA SYKLEVYTLN GEKIKEITFD VPGSLYPLDK DEERVLLRYT SFTIPYRLYE FKDDLRLIEE RKVEGEFRVE EDFATSKDGT KVHYFIVKGE RDEKRAWVFG YGGFNIALTP MFFPQVIPFL KRGGTFIMAN LRGGSEYGEE WHRAGMRENK QNVFDDFIAV LEKRKKEGYK VAAWGRSNGG LLVSATLTQR PDVMDSALIG YPVIDMLRFH KLYIGSVWIP EYGNPEDPKD REFLLKYSPY HNVDPKKKYP PTLIYTGLHD DRVHPAHALK FFMKLKEIGA PVYLRVETKS GHMGASPETR ARELTDLLAF VLKTLS //