ID   Q51714_PYRFU PRELIMINARY;      PRT;   616 AA.
AC   Q51714;
DT   01-JAN-1998 (TrEMBLrel. 05, Created)
DT   01-JAN-1998 (TrEMBLrel. 05, Last sequence update)
DT   01-OCT-2003 (TrEMBLrel. 25, Last annotation update)
DE   Prolyl endopeptidase.
OS   Pyrococcus furiosus.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=2261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 3638;
RX   MEDLINE=95129900; PubMed=7828913; DOI=10.1016/0378-1119(94)00688-O;
RA   Robinson K.A., Bartley D.A., Robb F.T., Schreier H.J.;
RT   "A gene from the hyperthermophile Pyrococcus furiosus whose deduced
RT   product is homologous to members of the prolyl oligopeptidase family
RT   of proteases.";
RL   Gene 152:103-106(1995).
CC   -!- FUNCTION: Cleaves peptide bonds on the C-terminal side of prolyl
CC       residues within peptides that are up to approximately 30 amino
CC       acids long. Has an absolute requirement for an X-Pro bond in the
CC       trans configuration immediately preceding the Pro-Y scissible bond
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in
CC       oligopeptides.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U08343; AAA73423.1; -.
DR   PIR; JC4084; JC4084.
DR   HSSP; P23687; 1H2X.
DR   MEROPS; S09.002; -.
DR   GO; GO:0004287; F:prolyl oligopeptidase activity; IEA.
DR   GO; GO:0006508; P:proteolysis and peptidolysis; IEA.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   InterPro; IPR004106; Peptidase_S9A_N.
DR   InterPro; IPR000379; Ser_estrs.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
KW   Hydrolase; Protease; Serine protease.
SQ   SEQUENCE   616 AA;  70867 MW;  7C42561D7D187F2D CRC64;
     MEDPYIWMEN LEDERVLKII EEENKRFREF IGELSDKLFP EVWEQFSQPT IGMARITKKG
     IIASYSEKDR VVIKWFNGDV IVDSKELERE VGDEVLLQGF TTDEEGEKLA YSFSIGGADE
     GITRIIDLKT GEVIEEIKPS IWNITFLKDG YYFTRFYRKE KTPDGVNPPA ARMFWKDREG
     ERMVFGEGLT SGYFMSIRKS SDGKFAIVTL TYGWNQGEVY IGPIDNPQEW KKVYSASVPV
     EAIDVVNGKL YILTKEGKGL GKIIAIKNGK IDEVIPEGEF PLEWAVIVRD KILAGRLVHA
     SYKLEVYTLN GEKIKEITFD VPGSLYPLDK DEERVLLRYT SFTIPYRLYE FKDDLRLIEE
     RKVEGEFRVE EDFATSKDGT KVHYFIVKGE RDEKRAWVFG YGGFNIALTP MFFPQVIPFL
     KRGGTFIMAN LRGGSEYGEE WHRAGMRENK QNVFDDFIAV LEKRKKEGYK VAAWGRSNGG
     LLVSATLTQR PDVMDSALIG YPVIDMLRFH KLYIGSVWIP EYGNPEDPKD REFLLKYSPY
     HNVDPKKKYP PTLIYTGLHD DRVHPAHALK FFMKLKEIGA PVYLRVETKS GHMGASPETR
     ARELTDLLAF VLKTLS
//