ID Q51714_PYRFU PRELIMINARY; PRT; 616 AA. AC Q51714; DT 01-JAN-1998 (TrEMBLrel. 05, Created) DT 01-JAN-1998 (TrEMBLrel. 05, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE Prolyl endopeptidase. OS Pyrococcus furiosus. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=2261; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=DSM 3638; RX MEDLINE=95129900; PubMed=7828913; DOI=10.1016/0378-1119(94)00688-O; RA Robinson K.A., Bartley D.A., Robb F.T., Schreier H.J.; RT "A gene from the hyperthermophile Pyrococcus furiosus whose deduced RT product is homologous to members of the prolyl oligopeptidase family RT of proteases."; RL Gene 152:103-106(1995). CC -!- FUNCTION: Cleaves peptide bonds on the C-terminal side of prolyl CC residues within peptides that are up to approximately 30 amino CC acids long. Has an absolute requirement for an X-Pro bond in the CC trans configuration immediately preceding the Pro-Y scissible bond CC (By similarity). CC -!- CATALYTIC ACTIVITY: Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in CC oligopeptides. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U08343; AAA73423.1; -. DR PIR; JC4084; JC4084. DR HSSP; P23687; 1H2X. DR MEROPS; S09.002; -. DR GO; GO:0004287; F:prolyl oligopeptidase activity; IEA. DR GO; GO:0006508; P:proteolysis and peptidolysis; IEA. DR InterPro; IPR001375; Peptidase_S9. DR InterPro; IPR002470; Peptidase_S9A. DR InterPro; IPR004106; Peptidase_S9A_N. DR InterPro; IPR000379; Ser_estrs. DR Pfam; PF00326; Peptidase_S9; 1. DR Pfam; PF02897; Peptidase_S9_N; 1. DR PRINTS; PR00862; PROLIGOPTASE. KW Hydrolase; Protease; Serine protease. SQ SEQUENCE 616 AA; 70867 MW; 7C42561D7D187F2D CRC64; MEDPYIWMEN LEDERVLKII EEENKRFREF IGELSDKLFP EVWEQFSQPT IGMARITKKG IIASYSEKDR VVIKWFNGDV IVDSKELERE VGDEVLLQGF TTDEEGEKLA YSFSIGGADE GITRIIDLKT GEVIEEIKPS IWNITFLKDG YYFTRFYRKE KTPDGVNPPA ARMFWKDREG ERMVFGEGLT SGYFMSIRKS SDGKFAIVTL TYGWNQGEVY IGPIDNPQEW KKVYSASVPV EAIDVVNGKL YILTKEGKGL GKIIAIKNGK IDEVIPEGEF PLEWAVIVRD KILAGRLVHA SYKLEVYTLN GEKIKEITFD VPGSLYPLDK DEERVLLRYT SFTIPYRLYE FKDDLRLIEE RKVEGEFRVE EDFATSKDGT KVHYFIVKGE RDEKRAWVFG YGGFNIALTP MFFPQVIPFL KRGGTFIMAN LRGGSEYGEE WHRAGMRENK QNVFDDFIAV LEKRKKEGYK VAAWGRSNGG LLVSATLTQR PDVMDSALIG YPVIDMLRFH KLYIGSVWIP EYGNPEDPKD REFLLKYSPY HNVDPKKKYP PTLIYTGLHD DRVHPAHALK FFMKLKEIGA PVYLRVETKS GHMGASPETR ARELTDLLAF VLKTLS //