ID FPRA_METTM Reviewed; 404 AA. AC Q50497; DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 20-APR-2010, entry version 53. DE RecName: Full=Type A flavoprotein fprA; DE EC=1.-.-.-; DE AltName: Full=FMN protein fprA; DE AltName: Full=Flavoprotein A; GN Name=fprA; Synonyms=fpaA; OS Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133). OC Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; OC Methanobacteriaceae; Methanothermobacter. OX NCBI_TaxID=79929; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], COFACTOR, AND PROTEIN SEQUENCE OF RP 1-31. RX MEDLINE=95247678; PubMed=7730275; RA Wasserfallen A., Huber K., Leisinger T.; RT "Purification and structural characterization of a flavoprotein RT induced by iron limitation in Methanobacterium thermoautotrophicum RT Marburg."; RL J. Bacteriol. 177:2436-2441(1995). RN [2] RP PROTEIN SEQUENCE OF 1-22, AND COFACTOR. RX MEDLINE=95377292; PubMed=7649162; RX DOI=10.1111/j.1432-1033.1995.0628d.x; RA Noelling J., Ishii M., Koch J., Pihl T.D., Reeve J.N., Thauer R.K., RA Hedderich R.; RT "Characterization of a 45-kDa flavoprotein and evidence for a RT rubredoxin, two proteins that could participate in electron transport RT from H2 to CO2 in methanogenesis in Methanobacterium RT thermoautotrophicum."; RL Eur. J. Biochem. 231:628-638(1995). RN [3] RP DISCUSSION OF FUNCTION. RX MEDLINE=98321624; PubMed=9660187; RX DOI=10.1046/j.1432-1327.1998.2540325.x; RA Wasserfallen A., Ragettli S., Jouanneau Y., Leisinger T.; RT "A family of flavoproteins in the domains Archaea and Bacteria."; RL Eur. J. Biochem. 254:325-332(1998). CC -!- FUNCTION: Probably functions as an electron acceptor for a CC hydrogenase; however there is an uncharacterized intermediate CC between the hydrogenase and flavoprotein A. CC -!- COFACTOR: Binds 1 FMN per subunit. CC -!- SUBUNIT: Homodimer or homotetramer. CC -!- INDUCTION: By iron limitation. CC -!- SIMILARITY: In the N-terminal section; belongs to the zinc CC metallo-hydrolase group 3 family. CC -!- SIMILARITY: Contains 1 flavodoxin-like domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U17835; AAB88013.1; -; Genomic_DNA. DR PDB; 2OHH; X-ray; 1.70 A; A/B/D/E=1-404. DR PDB; 2OHI; X-ray; 2.30 A; A/B/D/E/G/H/I/J=1-404. DR PDB; 2OHJ; X-ray; 2.26 A; A/B/D/E=1-404. DR PDBsum; 2OHH; -. DR PDBsum; 2OHI; -. DR PDBsum; 2OHJ; -. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0010181; F:FMN binding; IEA:InterPro. DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR001279; Blactmase-like. DR InterPro; IPR008254; Flavodoxin/NO_synth. DR InterPro; IPR001226; Flavodoxin_CS. DR InterPro; IPR000014; PAS. DR InterPro; IPR016440; Rubredoxin-O_OxRdtase. DR Pfam; PF00258; Flavodoxin_1; 1. DR PIRSF; PIRSF005243; ROO; 1. DR SMART; SM00849; Lactamase_B; 1. DR SMART; SM00091; PAS; 1. DR PROSITE; PS00201; FLAVODOXIN; 1. DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Electron transport; KW Flavoprotein; FMN; Iron; Metal-binding; Oxidoreductase; Transport. FT CHAIN 1 404 Type A flavoprotein fprA. FT /FTId=PRO_0000216808. FT DOMAIN 259 399 Flavodoxin-like. FT REGION 30 206 Zinc metallo-hydrolase. FT METAL 83 83 Iron 1 (By similarity). FT METAL 85 85 Iron 1 (By similarity). FT METAL 87 87 Iron 2 (By similarity). FT METAL 151 151 Iron 1 (By similarity). FT METAL 170 170 Iron 1 (By similarity). FT METAL 170 170 Iron 2 (By similarity). FT METAL 233 233 Iron 2 (By similarity). FT STRAND 6 9 FT STRAND 12 14 FT STRAND 17 19 FT STRAND 33 35 FT STRAND 38 41 FT STRAND 46 49 FT HELIX 57 71 FT STRAND 78 80 FT HELIX 86 89 FT HELIX 92 98 FT STRAND 104 106 FT HELIX 108 117 FT HELIX 119 123 FT STRAND 126 128 FT STRAND 134 136 FT STRAND 141 146 FT STRAND 150 152 FT STRAND 156 161 FT TURN 162 164 FT STRAND 165 167 FT TURN 169 172 FT HELIX 183 185 FT HELIX 188 202 FT HELIX 204 206 FT HELIX 207 219 FT HELIX 223 225 FT STRAND 227 230 FT STRAND 232 234 FT STRAND 236 239 FT HELIX 240 251 FT STRAND 257 263 FT STRAND 266 268 FT HELIX 269 282 FT TURN 283 285 FT STRAND 287 292 FT TURN 293 295 FT HELIX 298 306 FT STRAND 309 314 FT HELIX 325 336 FT HELIX 338 340 FT STRAND 344 355 FT HELIX 358 368 FT STRAND 371 382 FT HELIX 385 402 SQ SEQUENCE 404 AA; 45205 MW; 155AF7D9FE9D75FD CRC64; MKAAAKRISD GVYWTGVLDW DLRNYHGYTL QGTTYNAYLV CGDEGVALID NSYPGTFDEL MARVEDALQQ VGMERVDYII QNHVEKDHSG VLVELHRRFP EAPIYCTEVA VKGLLKHYPS LREAEFMTVK TGDVLDLGGK TLTFLETPLL HWPDSMFTLL DEDGILFSND AFGQHLCCPQ RLDREIPEYI LMDAARKFYA NLITPLSKLV LKKFDEVKEL GLLERIQMIA PSHGQIWTDP MKIIEAYTGW ATGMVDERVT VIYDTMHGST RKMAHAIAEG AMSEGVDVRV YCLHEDDRSE IVKDILESGA IALGAPTIYD EPYPSVGDLL MYLRGLKFNR TLTRKALVFG SMGGNGGATG TMKELLAEAG FDVACEEEVY YVPTGDELDA CFEAGRKLAA EIRR //