ID   CCD38_HUMAN             Reviewed;         563 AA.
AC   Q502W7; Q8N835;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   22-APR-2020, entry version 95.
DE   RecName: Full=Coiled-coil domain-containing protein 38;
GN   Name=CCDC38;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=25074808; DOI=10.1242/jcs.157008;
RA   Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT   "Proteomic analysis of mammalian sperm cells identifies new components of
RT   the centrosome.";
RL   J. Cell Sci. 127:4128-4133(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:25074808}.
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DR   EMBL; AK097408; BAC05038.1; -; mRNA.
DR   EMBL; BC095479; AAH95479.1; -; mRNA.
DR   CCDS; CCDS9056.1; -.
DR   RefSeq; NP_872302.2; NM_182496.2.
DR   RefSeq; XP_011536185.1; XM_011537883.2.
DR   SMR; Q502W7; -.
DR   IntAct; Q502W7; 2.
DR   STRING; 9606.ENSP00000345470; -.
DR   iPTMnet; Q502W7; -.
DR   PhosphoSitePlus; Q502W7; -.
DR   BioMuta; CCDC38; -.
DR   DMDM; 74740178; -.
DR   EPD; Q502W7; -.
DR   jPOST; Q502W7; -.
DR   MassIVE; Q502W7; -.
DR   PaxDb; Q502W7; -.
DR   PeptideAtlas; Q502W7; -.
DR   PRIDE; Q502W7; -.
DR   ProteomicsDB; 62398; -.
DR   Antibodypedia; 49794; 112 antibodies.
DR   Ensembl; ENST00000344280; ENSP00000345470; ENSG00000165972.
DR   GeneID; 120935; -.
DR   KEGG; hsa:120935; -.
DR   UCSC; uc001tek.3; human.
DR   CTD; 120935; -.
DR   DisGeNET; 120935; -.
DR   GeneCards; CCDC38; -.
DR   HGNC; HGNC:26843; CCDC38.
DR   HPA; ENSG00000165972; Tissue enriched (testis).
DR   neXtProt; NX_Q502W7; -.
DR   OpenTargets; ENSG00000165972; -.
DR   PharmGKB; PA142672193; -.
DR   eggNOG; ENOG410IFH9; Eukaryota.
DR   eggNOG; ENOG410YEAI; LUCA.
DR   GeneTree; ENSGT00940000153110; -.
DR   HOGENOM; CLU_026271_1_0_1; -.
DR   InParanoid; Q502W7; -.
DR   OMA; HSKPPSG; -.
DR   OrthoDB; 1092113at2759; -.
DR   PhylomeDB; Q502W7; -.
DR   TreeFam; TF328835; -.
DR   GenomeRNAi; 120935; -.
DR   Pharos; Q502W7; Tdark.
DR   PRO; PR:Q502W7; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q502W7; protein.
DR   Bgee; ENSG00000165972; Expressed in right testis and 99 other tissues.
DR   ExpressionAtlas; Q502W7; baseline and differential.
DR   Genevisible; Q502W7; HS.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   InterPro; IPR025252; DUF4200.
DR   Pfam; PF13863; DUF4200; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome.
FT   CHAIN           1..563
FT                   /note="Coiled-coil domain-containing protein 38"
FT                   /id="PRO_0000234490"
FT   COILED          129..212
FT                   /evidence="ECO:0000255"
FT   COILED          384..415
FT                   /evidence="ECO:0000255"
FT   COILED          497..522
FT                   /evidence="ECO:0000255"
FT   VARIANT         36
FT                   /note="V -> F (in dbSNP:rs12368787)"
FT                   /id="VAR_056778"
FT   VARIANT         227
FT                   /note="M -> V (in dbSNP:rs10859974)"
FT                   /id="VAR_056779"
FT   CONFLICT        530
FT                   /note="R -> Q (in Ref. 1; BAC05038)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   563 AA;  65315 MW;  1B1EAC0005CC4B47 CRC64;
     MSSNLLPTLN SGGKVKDGST KEDRPYKIFF RDLFLVKENE MAAKETEKFM NRNMKVYQKT
     TFSSRMKSHS YLSQLAFYPK RSGRSFEKFG PGPAPIPRLI EGSDTKRTVH EFINDQRDRF
     LLEYALSTKR NTIKKFEKDI AMRERQLKKA EKKLQDDALA FEEFLRENDQ RSVDALKMAA
     QETINKLQMT AELKKASMEV QAVKSEIAKT EFLLREYMKY GFFLLQMSPK HWQIQQALKR
     AQASKSKANI ILPKILAKLS LHSSNKEGIL EESGRTAVLS EDASQGRDSQ GKPSRSLTRT
     PEKKKSNLAE SFGSEDSLEF LLDDEMDVDL EPALYFKEPE ELLQVLRELE EQNLTLFQYS
     QDVDENLEEV NKREKVIQDK TNSNIEFLLE QEKMLKANCV REEEKAAELQ LKSKLFSFGE
     FNSDAQEILI DSLSKKITQV YKVCIGDAED DGLNPIQKLV KVESRLVELC DLIESIPKEN
     VEAIERMKQK EWRQKFRDEK MKEKQRHQQE RLKAALEKAV AQPKKKLGRR LVFHSKPPSG
     NKQQLPLVNE TKTKSQEEEY FFT
//