ID FNDC1_HUMAN Reviewed; 1888 AA. AC Q4ZHG4; Q5JPI0; Q5VU31; Q5VU32; Q5VXX4; Q70CQ6; Q96JG1; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 3. DT 24-NOV-2009, entry version 43. DE RecName: Full=Fibronectin type III domain-containing protein 1; DE AltName: Full=Expressed in synovial lining protein; DE AltName: Full=Activation-associated cDNA protein; DE Flags: Precursor; GN Name=FNDC1; Synonyms=FNDC2, KIAA1866, MEL4B3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-1261. RX MEDLINE=98368331; PubMed=9704633; RX DOI=10.1002/1529-0131(199808)41:8<1356::AID-ART4>3.0.CO;2-X; RA Seki T., Selby J., Haupl T., Winchester R.; RT "Use of differential subtraction method to identify genes that RT characterize the phenotype of cultured rheumatoid arthritis RT synoviocytes."; RL Arthritis Rheum. 41:1356-1364(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS LEU-1261 RP AND THR-1498. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1888 (ISOFORM 2), AND RP VARIANTS GLN-463; GLU-1003; GLU-1180 AND ARG-1280. RC TISSUE=Brain; RX MEDLINE=21245130; PubMed=11347906; DOI=10.1093/dnares/8.2.85; RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XX. RT The complete sequences of 100 new cDNA clones from brain which code RT for large proteins in vitro."; RL DNA Res. 8:85-95(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1196-1888 (ISOFORM 1), AND RP VARIANT ARG-1280. RC TISSUE=Lymph node; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1295-1888 (ISOFORM 1), AND INDUCTION BY RP TGF-BETA. RX PubMed=16098131; DOI=10.1111/j.0906-6705.2005.00349.x; RA Anderegg U., Breitschwerdt K., Koehler M.J., Sticherling M., RA Haustein U.-F., Simon J.C., Saalbach A.; RT "MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF- RT beta and pro-inflammatory cytokines."; RL Exp. Dermatol. 14:709-718(2005). CC -!- FUNCTION: May be an activator of G protein signaling (By CC similarity). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q4ZHG4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q4ZHG4-2; Sequence=VSP_024663; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Almost absent from healthy skin; especially in CC epidermal keratinocytes, skin fibroblasts or endothelial cells and CC is barely detectable in benign melanocytic naevi. Expressed in the CC stroma close to skin tumors, in the tumor cells themselves and in CC the epidermis of psoriasis. CC -!- INDUCTION: By TGF-beta present in the melanoma cell conditioned CC medium (MCCM). CC -!- SIMILARITY: Contains 5 fibronectin type-III domains. CC -!- CAUTION: It is uncertain whether Met-1 or Met-53 is the initiator. CC -!- SEQUENCE CAUTION: CC Sequence=CAE51894.1; Type=Frameshift; Positions=1481; CC Sequence=CAH70504.1; Type=Erroneous gene model prediction; CC Sequence=CAH71650.1; Type=Erroneous gene model prediction; CC Sequence=CAH71651.1; Type=Erroneous gene model prediction; CC Sequence=CAI20153.1; Type=Erroneous gene model prediction; CC Sequence=CAI20154.1; Type=Erroneous gene model prediction; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ009660; AAY26234.1; ALT_INIT; mRNA. DR EMBL; AL356417; CAH70504.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL355492; CAH70504.1; JOINED; Genomic_DNA. DR EMBL; AL590551; CAH71650.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL590551; CAH71651.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL355492; CAH71651.1; JOINED; Genomic_DNA. DR EMBL; AL355492; CAI20153.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL590551; CAI20153.1; JOINED; Genomic_DNA. DR EMBL; AL355492; CAI20154.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL356417; CAI20154.1; JOINED; Genomic_DNA. DR EMBL; AB058769; BAB47495.2; ALT_INIT; mRNA. DR EMBL; AL832410; CAI46178.2; -; mRNA. DR EMBL; AJ586132; CAE51894.1; ALT_FRAME; mRNA. DR IPI; IPI00306457; -. DR IPI; IPI00844416; -. DR RefSeq; NP_115921.2; -. DR UniGene; Hs.520525; -. DR HSSP; Q9HCK4; 1UEM. DR STRING; Q4ZHG4; -. DR PhosphoSite; Q4ZHG4; -. DR PeptideAtlas; Q4ZHG4; -. DR Ensembl; ENST00000297267; ENSP00000297267; ENSG00000164694; Homo sapiens. DR GeneID; 84624; -. DR KEGG; hsa:84624; -. DR UCSC; uc010kjv.1; human. DR UCSC; uc010kjw.1; human. DR CTD; 84624; -. DR GeneCards; GC06P159609; -. DR HGNC; HGNC:21184; FNDC1. DR MIM; 609991; gene. DR PharmGKB; PA134906656; -. DR HOVERGEN; Q4ZHG4; -. DR NextBio; 74520; -. DR ArrayExpress; Q4ZHG4; -. DR Bgee; Q4ZHG4; -. DR CleanEx; HS_FNDC1; -. DR Genevestigator; Q4ZHG4; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR003961; FN_III. DR Pfam; PF00041; fn3; 5. DR SMART; SM00060; FN3; 5. DR PROSITE; PS50853; FN3; 5. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Glycoprotein; Polymorphism; KW Repeat; Secreted; Signal. FT SIGNAL 1 32 Potential. FT CHAIN 33 1888 Fibronectin type III domain-containing FT protein 1. FT /FTId=PRO_0000284831. FT DOMAIN 40 129 Fibronectin type-III 1. FT DOMAIN 158 250 Fibronectin type-III 2. FT DOMAIN 259 354 Fibronectin type-III 3. FT DOMAIN 359 453 Fibronectin type-III 4. FT DOMAIN 1649 1743 Fibronectin type-III 5. FT COMPBIAS 671 773 Ser-rich. FT COMPBIAS 1443 1510 Thr-rich. FT CARBOHYD 149 149 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1655 1655 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 394 457 EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFK FT IRATNRRGLGPHSKAFIVAMPTT -> A (in isoform FT 2). FT /FTId=VSP_024663. FT VARIANT 438 438 T -> A (in dbSNP:rs509648). FT /FTId=VAR_031826. FT VARIANT 463 463 E -> Q (in dbSNP:rs420137). FT /FTId=VAR_031827. FT VARIANT 1003 1003 Q -> E (in dbSNP:rs370434). FT /FTId=VAR_031828. FT VARIANT 1180 1180 D -> E (in dbSNP:rs420054). FT /FTId=VAR_031829. FT VARIANT 1261 1261 P -> L (in dbSNP:rs3003174). FT /FTId=VAR_031830. FT VARIANT 1280 1280 Q -> R (in dbSNP:rs2501176). FT /FTId=VAR_031831. FT VARIANT 1498 1498 K -> T (in dbSNP:rs386360). FT /FTId=VAR_031832. FT VARIANT 1568 1568 T -> A (in dbSNP:rs7763726). FT /FTId=VAR_031833. FT CONFLICT 36 36 S -> P (in Ref. 1; AAY26234). FT CONFLICT 1295 1295 M -> K (in Ref. 5; CAE51894). FT CONFLICT 1478 1478 T -> TTRRTTT (in Ref. 2; CAH71650). FT CONFLICT 1679 1679 D -> N (in Ref. 5; CAE51894). FT CONFLICT 1888 1888 W -> G (in Ref. 5; CAE51894). SQ SEQUENCE 1888 AA; 204852 MW; 9957EE1D42A1B180 CRC64; MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR PPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTRR PTTTVRTTTR TTTTTTPKPT TPIPTCPPGT LERHDDDGNL IMSSNGIPEC YAEEDEFSGL ETDTAVPTEE AYVIYDEDYE FETSRPPTTT EPSTTATTPR VIPEEGAISS FPEEEFDLAG RKRFVAPYVT YLNKDPSAPC SLTDALDHFQ VDSLDEIIPN DLKKSDLPPQ HAPRNITVVA VEGCHSFVIV DWDKATPGDV VTGYLVYSAS YEDFIRNKWS TQASSVTHLP IENLKPNTRY YFKVQAQNPH GYGPISPSVS FVTESDNPLL VVRPPGGEPI WIPFAFKHDP SYTDCHGRQY VKRTWYRKFV GVVLCNSLRY KIYLSDNLKD TFYSIGDSWG RGEDHCQFVD SHLDGRTGPQ SYVEALPTIQ GYYRQYRQEP VRFGNIGFGT PYYYVGWYEC GVSIPGKW //