ID FNDC1_HUMAN Reviewed; 1894 AA. AC Q4ZHG4; A6H8X2; B7ZBR4; B7ZBR5; B9EK49; Q5JPI0; Q5VU31; Q5VU32; Q5VXX4; AC Q70CQ6; Q96JG1; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 15-JUN-2010, sequence version 4. DT 29-SEP-2021, entry version 135. DE RecName: Full=Fibronectin type III domain-containing protein 1; DE AltName: Full=Activation-associated cDNA protein; DE AltName: Full=Expressed in synovial lining protein; DE Flags: Precursor; GN Name=FNDC1; Synonyms=FNDC2, KIAA1866, MEL4B3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS 1479-THR--THR-1484 DEL RP AND LYS-1504. RX PubMed=9704633; RX DOI=10.1002/1529-0131(199808)41:8<1356::aid-art4>3.0.co;2-x; RA Seki T., Selby J., Haupl T., Winchester R.; RT "Use of differential subtraction method to identify genes that characterize RT the phenotype of cultured rheumatoid arthritis synoviocytes."; RL Arthritis Rheum. 41:1356-1364(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORM 2), AND VARIANTS RP GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND RP LYS-1504. RC TISSUE=Brain; RX PubMed=11347906; DOI=10.1093/dnares/8.2.85; RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XX. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 8:85-95(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORMS 1 AND 2), AND RP VARIANTS ALA-438; GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; RP 1479-THR--THR-1484 DEL AND LYS-1504. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1196-1894 (ISOFORM 1), AND RP VARIANTS PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504. RC TISSUE=Lymph node; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1295-1894 (ISOFORM 1), INDUCTION BY TGFB1, RP AND VARIANTS 1479-THR--THR-1484 DEL AND LYS-1504. RX PubMed=16098131; DOI=10.1111/j.0906-6705.2005.00349.x; RA Anderegg U., Breitschwerdt K., Koehler M.J., Sticherling M., RA Haustein U.-F., Simon J.C., Saalbach A.; RT "MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta RT and pro-inflammatory cytokines."; RL Exp. Dermatol. 14:709-718(2005). CC -!- FUNCTION: May be an activator of G protein signaling. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q4ZHG4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q4ZHG4-2; Sequence=VSP_024663; CC -!- TISSUE SPECIFICITY: Almost absent from healthy skin; especially in CC epidermal keratinocytes, skin fibroblasts or endothelial cells and is CC barely detectable in benign melanocytic naevi. Expressed in the stroma CC close to skin tumors, in the tumor cells themselves and in the CC epidermis of psoriasis. CC -!- INDUCTION: By TGFB1 present in the melanoma cell conditioned medium CC (MCCM). {ECO:0000269|PubMed:16098131}. CC -!- CAUTION: It is uncertain whether Met-1 or Met-53 is the initiator. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAI46784.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAI50608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAY26234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAE51894.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ009660; AAY26234.1; ALT_INIT; mRNA. DR EMBL; AL355492; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL356417; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL590551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB058769; BAB47495.2; -; mRNA. DR EMBL; BC146783; AAI46784.1; ALT_INIT; mRNA. DR EMBL; BC150607; AAI50608.1; ALT_INIT; mRNA. DR EMBL; AL832410; CAI46178.2; -; mRNA. DR EMBL; AJ586132; CAE51894.1; ALT_FRAME; mRNA. DR CCDS; CCDS47512.1; -. [Q4ZHG4-1] DR RefSeq; NP_115921.2; NM_032532.2. [Q4ZHG4-1] DR SMR; Q4ZHG4; -. DR STRING; 9606.ENSP00000297267; -. DR GlyGen; Q4ZHG4; 3 sites, 1 O-linked glycan (1 site). DR iPTMnet; Q4ZHG4; -. DR PhosphoSitePlus; Q4ZHG4; -. DR BioMuta; FNDC1; -. DR DMDM; 298286926; -. DR jPOST; Q4ZHG4; -. DR MassIVE; Q4ZHG4; -. DR PaxDb; Q4ZHG4; -. DR PeptideAtlas; Q4ZHG4; -. DR PRIDE; Q4ZHG4; -. DR ProteomicsDB; 62382; -. [Q4ZHG4-1] DR ProteomicsDB; 62383; -. [Q4ZHG4-2] DR Antibodypedia; 50561; 40 antibodies. DR DNASU; 84624; -. DR Ensembl; ENST00000297267; ENSP00000297267; ENSG00000164694. [Q4ZHG4-1] DR GeneID; 84624; -. DR KEGG; hsa:84624; -. DR UCSC; uc010kjv.4; human. [Q4ZHG4-1] DR CTD; 84624; -. DR DisGeNET; 84624; -. DR GeneCards; FNDC1; -. DR HGNC; HGNC:21184; FNDC1. DR HPA; ENSG00000164694; Tissue enhanced (thyroid). DR MIM; 609991; gene. DR neXtProt; NX_Q4ZHG4; -. DR OpenTargets; ENSG00000164694; -. DR PharmGKB; PA134906656; -. DR VEuPathDB; HostDB:ENSG00000164694; -. DR eggNOG; KOG4221; Eukaryota. DR GeneTree; ENSGT00530000063558; -. DR HOGENOM; CLU_002998_0_0_1; -. DR InParanoid; Q4ZHG4; -. DR OMA; GTLEQHD; -. DR OrthoDB; 46073at2759; -. DR PhylomeDB; Q4ZHG4; -. DR TreeFam; TF337588; -. DR PathwayCommons; Q4ZHG4; -. DR BioGRID-ORCS; 84624; 5 hits in 1001 CRISPR screens. DR ChiTaRS; FNDC1; human. DR GenomeRNAi; 84624; -. DR Pharos; Q4ZHG4; Tbio. DR PRO; PR:Q4ZHG4; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q4ZHG4; protein. DR Bgee; ENSG00000164694; Expressed in layer of synovial tissue and 152 other tissues. DR ExpressionAtlas; Q4ZHG4; baseline and differential. DR Genevisible; Q4ZHG4; HS. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IDA:HPA. DR CDD; cd00063; FN3; 5. DR Gene3D; 2.60.40.10; -; 5. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR Pfam; PF00041; fn3; 4. DR SMART; SM00060; FN3; 5. DR SUPFAM; SSF49265; SSF49265; 3. DR PROSITE; PS50853; FN3; 5. PE 2: Evidence at transcript level; KW Alternative splicing; Glycoprotein; Phosphoprotein; Reference proteome; KW Repeat; Secreted; Signal. FT SIGNAL 1..32 FT /evidence="ECO:0000255" FT CHAIN 33..1894 FT /note="Fibronectin type III domain-containing protein 1" FT /id="PRO_0000284831" FT DOMAIN 39..131 FT /note="Fibronectin type-III 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 158..258 FT /note="Fibronectin type-III 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 262..357 FT /note="Fibronectin type-III 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 362..457 FT /note="Fibronectin type-III 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 1658..1752 FT /note="Fibronectin type-III 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REGION 455..500 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 515..1271 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1311..1350 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1444..1515 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 619..641 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 669..683 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 752..782 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 784..800 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 840..858 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 861..887 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 904..928 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 932..971 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1000..1014 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1015..1074 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1239..1253 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1444..1505 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 717 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q2Q0I9" FT CARBOHYD 149 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1661 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 394..457 FT /note="EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGP FT HSKAFIVAMPTT -> A (in isoform 2)" FT /evidence="ECO:0000303|PubMed:11347906, FT ECO:0000303|PubMed:15489334" FT /id="VSP_024663" FT VARIANT 438 FT /note="T -> A (in dbSNP:rs509648)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_031826" FT VARIANT 463 FT /note="E -> Q (in dbSNP:rs420137)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334" FT /id="VAR_031827" FT VARIANT 1003 FT /note="Q -> E (in dbSNP:rs370434)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334" FT /id="VAR_031828" FT VARIANT 1180 FT /note="D -> E (in dbSNP:rs420054)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334" FT /id="VAR_031829" FT VARIANT 1261 FT /note="L -> P (in dbSNP:rs3003174)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005" FT /id="VAR_031830" FT VARIANT 1280 FT /note="Q -> R (in dbSNP:rs2501176)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005" FT /id="VAR_031831" FT VARIANT 1479..1484 FT /note="Missing (in dbSNP:rs3842694)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131, FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633" FT /id="VAR_063225" FT VARIANT 1504 FT /note="T -> K (in dbSNP:rs386360)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131, FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633" FT /id="VAR_031832" FT VARIANT 1574 FT /note="T -> A (in dbSNP:rs7763726)" FT /id="VAR_031833" FT CONFLICT 36 FT /note="S -> P (in Ref. 1; AAY26234)" FT /evidence="ECO:0000305" FT CONFLICT 122 FT /note="P -> S (in Ref. 4; AAI50608)" FT /evidence="ECO:0000305" FT CONFLICT 1295 FT /note="M -> K (in Ref. 6; CAE51894)" FT /evidence="ECO:0000305" FT CONFLICT 1487 FT /note="P -> S (in Ref. 6; CAE51894)" FT /evidence="ECO:0000305" FT CONFLICT 1685 FT /note="D -> N (in Ref. 6; CAE51894)" FT /evidence="ECO:0000305" FT CONFLICT 1894 FT /note="W -> G (in Ref. 6; CAE51894)" FT /evidence="ECO:0000305" SQ SEQUENCE 1894 AA; 205558 MW; 7A0A9D0445E511D8 CRC64; MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW //