ID SPC24_ASPFU Reviewed; 200 AA. AC Q4X0I7; DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot. DT 25-JUL-2006, sequence version 2. DT 24-JAN-2024, entry version 88. DE RecName: Full=Probable kinetochore protein spc24; GN Name=spc24; ORFNames=AFUA_2G13330; OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / OS Af293) (Neosartorya fumigata). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus; OC Aspergillus subgen. Fumigati. OX NCBI_TaxID=330879; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293; RX PubMed=16372009; DOI=10.1038/nature04332; RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L., RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., RA Barrell B.G., Denning D.W.; RT "Genomic sequence of the pathogenic and allergenic filamentous fungus RT Aspergillus fumigatus."; RL Nature 438:1151-1156(2005). CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated CC NDC80 complex, which is required for chromosome segregation and spindle CC checkpoint activity. {ECO:0000250}. CC -!- SUBUNIT: Component of the NDC80 complex, which consists of at least CC ndc80, nuf2 and spc24. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UST6}. CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UST6}. CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole CC body {ECO:0000250|UniProtKB:Q9UST6}. Note=Associated with kinetochores. CC {ECO:0000250|UniProtKB:Q9UST6}. CC -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=EAL93628.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAHF01000001; EAL93628.1; ALT_SEQ; Genomic_DNA. DR RefSeq; XP_755666.1; XM_750573.1. DR AlphaFoldDB; Q4X0I7; -. DR SMR; Q4X0I7; -. DR STRING; 330879.Q4X0I7; -. DR GeneID; 3513168; -. DR KEGG; afm:AFUA_2G13330; -. DR VEuPathDB; FungiDB:Afu2g13330; -. DR eggNOG; ENOG502S52R; Eukaryota. DR HOGENOM; CLU_091441_1_1_1; -. DR InParanoid; Q4X0I7; -. DR OrthoDB; 1801495at2759; -. DR Proteomes; UP000002530; Chromosome 2. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central. DR GO; GO:0031134; P:sister chromatid biorientation; ISS:UniProtKB. DR Gene3D; 3.30.160.430; -; 1. DR InterPro; IPR013252; Ndc80_Spc24. DR InterPro; IPR038066; Spc24_Fungi_globular_sf. DR PANTHER; PTHR22142:SF2; KINETOCHORE PROTEIN SPC24; 1. DR PANTHER; PTHR22142; UNCHARACTERIZED; 1. DR Pfam; PF08286; Spc24; 1. DR SUPFAM; SSF143026; Kinetochore globular domain; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Cytoplasm; KW Cytoskeleton; Kinetochore; Mitosis; Nucleus; Reference proteome. FT CHAIN 1..200 FT /note="Probable kinetochore protein spc24" FT /id="PRO_0000246658" FT COILED 39..129 FT /evidence="ECO:0000255" SQ SEQUENCE 200 AA; 22783 MW; 1A83BFE1FFA0958D CRC64; MLLDEDPATL IHHTIGNFNI QPDKQAVTRI NDSLSTLQQS RELRMRDAES ALRKLSRNLH ALTAQHEEAV SSHDSAKHAA QMVELDTKKF RIAKAATELE IESERLEGEL EMLKERLAEL EAQGLEGDEA TRREREADDA TILRLKIYRS LGIDIEADEA GNFSKAVIRN SRKGDVHVVN MDPKFSRFFY ANYFWSTMQG //